山西省阳泉市表型不一致同胞对的食管癌调查  

Epidemiological study of risk factors for esophageal cancer in Yangquan Area of Shanxi Province based on discordant sib pairs

作　　者：孙玉琳[1] 张金强[1] 毛永红 韩丽芬 马玉龙 林正伟[1] 周兰萍[1] 吴旻[1] 赵晓航[1,3] 

机构地区：[1]中国医学科学院北京协和医学院肿瘤研究所分子肿瘤学国家重点实验室,北京市100021 [2]山西省阳泉市肿瘤防治研究所,山西省阳泉市045000 [3]中国人民解放军海军总医院基础医学研究中心,北京市100048

出　　处：《世界华人消化杂志》2010年第16期1708-1713,共6页World Chinese Journal of Digestology

基　　金：国际科技合作与交流专项基金资助项目;No.2008DFA31130;国家高技术发展计划"863"基金资助项目;No.2006AA02Z19B;国家自然科学基金资助项目;No.30721001;No.30772507~~

摘　　要：目的:分析山西省阳泉市食管癌研究现场的环境暴露危险因素,为该地区食管癌综合防治提供理论依据.方法:建立以医院为基础的食管癌登记和随访体系,采用1∶1配对病例对照研究的方法,建立了127对信息完善的表型不一致同胞对.对所有研究对象进行面对面的问卷调查,并通过McNemar检验评价食管癌危险因素.结果:家庭收入低(OR=2.00,95%CI:1.14-3.52,P=0.0143)、食用热烫食物的习惯(OR=2.56,95%CI:1.44-4.57,P=0.0009)和重度饮酒(OR无穷大,P=0.0027)是该地区食管癌发病的危险因素.这些生活环境因素对有家族史的表型不一致同胞对的食管癌发病同样具有重要作用,OR(95%CI)值分别为2.18(1.07-4.45)、5.00(1.91-13.06)和无穷大.结论:除遗传因素以外,营养缺乏、吃烫食和重度饮酒是山西省阳泉市食管癌发病的主要危险因素,提示该地区从遗传因素和生活方式等多层次开展食管癌的综合防治具有重要意义.AIM： To explore the main environmental riskfactors for esophageal squamous cell carcinoma （ESCC） based on discordant sib pairs （DSPs） in a moderately high-incidence area, Yangquan City, Shanxi Province, and to provide theoretical evidence for developing effective control and prevention measures in this area. METHODS： A 1∶1 matched case-control study was carried out. One hundred and twenty-seven DSPs were recruited from the cancer registration and follow-up system of the local hospital. All ESCC cases and their matched unaffected sibs were subjected to a survey to obtain demographic information along with personal and family history, and lifestyle factors. The McNemar test was used for data analysis. RESULTS： Compared with matched unaffected sibs, low family income （OR = 2.00, 95%CI： 1.14-3.52, P = 0.0143）, hot food eating and drinking （OR = 2.56, 95%CI： 1.44-4.57, P = 0.0009） and heavy drinking （P = 0.0027） were risk factors for ESCC in the area. These factors play important roles in the development of ESCC, even in cases with a family history of ESCC, and the odds ratios （95%CI） were 2.18 （1.07-4.45）, 5.00（1.91-13.06） and infi nity, respectively. CONCLUSION： Besides genetic factors, lack of nutrition, hot food eating and heavy drinking are main risk factors for ESCC in Yangquan City. Prevention and control of ESCC should be intervened at multiple levels, such as genetic factors and lifestyles.

关 键 词：食管鳞癌 表型不一致同胞对 流行病学 危险因素 

分 类 号：R735.1[医药卫生—肿瘤]