胃泌素和生长抑素对人十二指肠粘膜表皮生长因子含量的影响  

Effects of gastrin and somatostatin on epidermal growth factor contents in human duodenal mucosa in vitro

作　　者：赵逵[1] 马淑玉[1] 何永恒[1] 宋剑[1] 龙小英[1] 高原[1] 刘模荣[1] 

机构地区：[1]遵义医学院附属医院

出　　处：《中国病理生理杂志》1999年第2期170-172,共3页Chinese Journal of Pathophysiology

摘　　要：目的和方法：通过体外孵育试验，研究胃泌素和生长抑素对十二指肠和十二指肠溃疡（Ｄｕ）旁粘膜表皮生长因子（ＥＧＦ）含量的影响。结果：活动期Ｄｕ旁粘膜ＥＧＦ含量减少，愈合期含量增高。五肽胃泌素可显著增加粘膜ＥＧＦ含量；生长抑素类似物奥曲肽可减少愈合期Ｄｕ旁粘膜ＥＧＦ含量，并有抑制五肽胃泌素增加ＥＧＦ含量的作用。结论：十二指肠粘膜ＥＧＦ含量减少可能是Ｄｕ的发病因素之一；胃泌素可刺激十二指肠粘膜ＥＧＦ合成。AIM and METHODS:Effects of gastrin and somatostatin on duodenal mucosal epidermal growth factor (EGF)contents were studied in normal subjects and patients with duodenal ulcer(Du).After duodenal biopsies were cultured in vitro for 24 h under various experimental conditions,EGF contents in homogenized biopsy specimens were determined by radioimmunoassy.RESULTS:EGF contents in mucosa around ulcer were decreased in active Du and increased in healing Du.EGF contents were increased significantly in normal and Du mucosa,when pentagastrin(100 μg/L and 200 μg/L)was added,and decreased markedly in healing Du mucosa after somatostatin analogue octreotide (10 μg/L and 20 μg/L)was added to the media.Addition of pentagastrin(200 μg/L)and octreotide(20 μg/L)together to the media,EGF contents were not changed in the mucosa of normal and Du.CONCLUSION:The fall of EGF contents in duodenal mucosa may be involved in the pathogenesis of Du.Gastrin can stimulate the production of EGF from duodenal mucosa and somatostatin can inhibite EGF production stimulated by gastrin in the mucosa.

关 键 词：表皮生长因子 胃泌素 生长抑素 十二指肠溃疡 

分 类 号：R573.102[医药卫生—消化系统]