GST-π和P-gp在胃癌中的表达及其临床意义  

Expression of GST-π and P-gp in gastric cancer

作　　者：凌斌勋[1] 陈环球[1] 徐新宇[1] 周兆飞[1] 陆建伟[1] 

机构地区：[1]江苏省肿瘤医院内科,南京210009

出　　处：《临床肿瘤学杂志》2010年第6期523-525,共3页Chinese Clinical Oncology

基　　金：江苏省社会发展科学计划项目基金资助(BS2007010);江苏省肿瘤医院基金资助(ZM200801)

摘　　要：目的探讨耐药蛋白GST-π和P-gp在胃癌中的表达及其与胃癌临床病理特征的关系。方法用免疫组化法检测209例胃癌组织GST-π和P-gp的表达情况,并收集临床病理相关资料作回顾性分析。结果 GST-π表达阳性率为81.82%(171/209),与淋巴结转移数目有关(P<0.05);P-gp表达阳性率为79.90%(167/209),在印戒细胞癌中表达率较高(P<0.05);GST-π和P-gp表达具有相关性(r=0.241,P<0.05)。结论 GST-π和P-gp的表达与胃癌的生物学行为有一定的相关性。Objective To study the relationship between the expression of GST-π and P-gp and pathological characteristics of gastric cancer.Methods The expressions of GST-π and P-gp in tumor specimens from patients with gastric cancer were detected by immunohistochemistry.Results The positive expression of GST-π was detected in 171 of 209 gastric cancer samples（81.82%）and was related to lymph node involvement（P〈0.05）.The positive expression of P-gp was detected in 167 of 209 gastric cancer samples（79.90%）and was higher in signet ring cell carcinoma（P〈0.05）.There was significant relationship between GST-π and P-gp expression（P〈0.05）.Conclusion The expression levels of GST-π and P-gp have closely relationships with biological behavior of human gastric cancer.

关 键 词：胃癌 GST-Π P-GP 

分 类 号：R735.2[医药卫生—肿瘤]