铁碳纳米粒的制备及其在肿瘤治疗中的应用  

Preparation of iron-carbon nanoparticles and its application in tumor therapy:Recent progress

作　　者：李彩坤[1] 蔡洪培[1] 

机构地区：[1]第二军医大学长征医院消化内科,上海200003

出　　处：《中国肿瘤生物治疗杂志》2010年第3期359-362,共4页Chinese Journal of Cancer Biotherapy

摘　　要：铁碳纳米粒分为铁碳纳米复合微粒和碳包铁纳米粒两类,可以通过机械研磨法、碳弧法、气相沉积法、热解法、爆炸法等方法制备。铁碳纳米粒具有较好的吸附作用和磁效应,是较为理想的化疗药物载体,用于搭载多柔比星、丝裂霉素、卡铂等化疗药物。铁碳纳米药物复合体具有载药量高、释放性能稳定的特点,能够维持抑制肿瘤细胞增殖的足够浓度,并有明显的靶器官聚集趋势,对靶器官以外组织的毒性作用大为降低;除此之外,铁碳纳米粒还具有磁感应发热效能,其发热效应跟磁性粒子的数量、浓度、感应电场作用时间有关,对肿瘤具有热杀伤作用。铁碳纳米粒作为药物载体抗肿瘤的研究在体内外实验中取得了重大进展,相信不久的将来,在临床肿瘤治疗中显示出良好的使用价值。Iron-carbon nanoparticles include iron-carbon nanoparticles,carbon-coated iron nanoparticles,etc.,which can be prepared by mechanical trituration,carbon arc,gas phase deposition,pyrolysis and explosion methods.Iron-carbon nanoparticles have good adsorptive and magnetic effects,and they are perfect carriers for chemotherapeutic drugs,such as adriamycin,mitomycin and carboplatin,etc.Iron-carbon nanoparticle complex has high-drug loading and stable release abilities,thus can maintain sufficient drug concentration for inhibition of tumor cell proliferation.In addition,they can greatly aggregate in target organs,reducing the adverse and toxic effects to non-target organs.Moreover,iron-carbon nanoparticles have magnetic induction ability and can kill tumor cells by thermogenic effects,whose intensity is correlated to the amount,concentration and action time of induced electric field.Great progress has been made in the research of iron-carbon nanoparticles as magnetic carriers for chemotherapeutic drugs in vitro and in vivo,and it is believed to have great values in clinical tumor therapy in future.

关 键 词：铁碳钠米粒 肿瘤 药物载体 磁感应 

分 类 号：R730.5[医药卫生—肿瘤] R979.1[医药卫生—临床医学]