重症急性胰腺炎患者血清抵抗素水平与胰腺坏死的关系  

The relationship of serum resistin and pancreatic necrosis in the patients with severe acute partieatitis

作　　者：马悦[1] 黄宗文[1] 夏庆[1] 薛平[1] 郭佳[1] 魏宏强[1] 何馥倩[1] 程征宇[1] 林子琦[1] 

机构地区：[1]四川大学华西医院中西医结合科,成都610041

出　　处：《中华胰腺病杂志》2010年第3期168-170,共3页Chinese Journal of Pancreatology

基　　金：基金项目：四川省中医药管理局基金资助（2007803）;四川省人事厅人才培养计划基金资助（07SRC-13）;国家科技支撑计划基金资助（2006BA104A15）

摘　　要：目的 探讨重症急性胰腺炎（SAP）患者血清抵抗素水平与胰腺坏死之间的关系.方法 对四川大学华西医院2008年3月至2008年11月收治的28例SAP患者进行前瞻性研究,根据CT结果分为坏死组和非坏死组,用酶联免疫吸附试验（ELISA）检测患者入院时的血清抵抗素浓度.对血清抵抗素预测胰腺坏死做ROC曲线分析.结果 非坏死组21例,坏死组7例,两组性别、年龄、基础疾病之间差别无统计学意义（P＞0.05）.26例SAP患者血清抵抗素浓度为（0.1730～7.4920）ng/ml,平均为（3.7102±1.6987）ng/ml.ROC曲线下面积为0.884±0.108,95%可信区间为0.672～1.097,渐近线信号0.003.据此得出P=0.003,＞0.50.结论 血清抵抗素可能对预测胰腺坏死有一定的临床应用价值.Objective To investigate the relationship of serum resistin and pancreatic necrosis in the patients with severe acute pancreatitis. Methods Twenty-eight patients with SAP admitted to our hospital from March 2008 to November 2008 were divided into two groups according to the CT scan imaging： necrotic group and non-necrotic group. The enzyme-linked immunosorbent assay （ELISA） was used to test the serum resistin levels. An ROC curve was depicted to predict the pancreas necrosis. Results There were 21 patients in the non-necrotic group and 7 in the necrotic group, and there was no significant difference in terms of sex, age and baseline disease （P〉0.05）. The resitin levels ranged from 0.1730 ng/ml to 7.4923 ng/ml, with a mean （3.7102±1.6987） ng/ml. The area under the curve of resistin values was 0.884±0.108 （95%CI：0.672～1.097）, asymptote signals 0.003, then it was calculated that P=0.003, which was〉0.50. Conclusions The serum resistin may be of clinical value to predict the pancreatic necrosis.

关 键 词：胰腺炎 急性坏死性 抵抗素 ROC曲线 

分 类 号：R576[医药卫生—消化系统]