多元醇通路与糖尿病性白内障  

Polyol pathway and diabetic cataract

作　　者：覃冬[1] 康刚劲[1] 

机构地区：[1]泸州医学院附属医院眼科,四川省泸州市646000

出　　处：《眼科新进展》2010年第7期698-700,共3页Recent Advances in Ophthalmology

摘　　要：糖尿病性白内障是一种发生视力渐进性损害的糖尿病常见慢性并发症,其发病机制尚未完全明确。但是,较多的研究表明,晶状体内的糖代谢紊乱是白内障形成的重要生化基础。多元醇通路是组织细胞葡萄糖代谢的重要途径,在糖尿病性白内障的发生、发展中具有重要的作用。本文就多元醇通路的生物化学特点,糖尿病性白内障晶状体混浊机制及其药物研究进展等方面的研究做一综述。Diabetic cataract is one of the common chronic complications of diabetes with the progressive eyesight damage.Its pathogenesis is inconclusive.However,more studies have shown that disorders of glucose metabolism within the lens is an important biochemical basis of cataract formation.Polyol pathway is an important way of glucose metabolism in tissues and cells,it also plays an important role in occurrence and development of diabetic cataract.This article reviewed the biochemical characteristics of polyol pathway,the mechanism of lens opacity and the research progression of drugs for diabetec cataract.

关 键 词：多元醇通路 糖尿病性白内障 药物研究 

分 类 号：R776.1[医药卫生—眼科]