一种大鼠心律失常模型的建立  

Establishment of an Aconite Fat-soluble Alkaloids Arrhythmia Model in Rats

作　　者：胡一冰[1] 彭成[2] 

机构地区：[1]成都大学生物产业学院,成都610106 [2]成都中医药大学药学院,成都610075

出　　处：《四川动物》2010年第4期627-629,共3页Sichuan Journal of Zoology

基　　金：国家自然科学基金重点项目(30230410)

摘　　要：目的建立一种新的心律失常动物模型。方法选用SD大鼠,经股静脉快速给予附子脂溶性生物碱0.425mg.kg^(-1),用四道生理记录仪持续记录心电图。结果附子脂溶性生物碱能够引起SD大鼠出现室性早搏、二联律或三联律、短时阵发性室性心动过速、连续性室性心动过速,继而以相反顺序逐渐恢复。用利多卡因反证治疗,与生理盐水相比差异极显著(P<0.001)。结论附子脂溶性生物碱注射致大鼠心律失常动物模型是一种可行的方法。Objective To establish a new animal model of arrhythmia on Sprague-Dawley rats. Methods To give aconite fat-soluble alkaloids 0.425 mg·kg-1 in the femoral vein rapidly and record the ECG with four-channel polygraph. Results Aconite fat-soluble alkaloids can induce premature ventricular contraction, bigeminy or trigeminy, short-term paroxysmal ventricular tachycardia, continuous ventrieular tachycardia, followed by a gradual in reverse order recovery. Treatment with lidocaine was significantly different than normal saline （P 〈 0.001 ）. Conclusion The establishment of an arrhythmia animal model in rats using aconite fat-soluble alkaloids is a feasible approach.

关 键 词：模型 心律失常 附子脂溶性生物碱 

分 类 号：R-332[医药卫生]