肺内骨外骨肉瘤1例病案报道及文献回顾  

Pulmonary extraskeletal osteosarcoma:a case report and review of literature

作　　者：韩秀娟[1] 李艳红 刘小艳[1] 巩丽[1] 朱少君[1] 姚丽[1] 兰淼[1] 赵建业[1] 张伟[1] 

机构地区：[1]第四军医大学唐都医院病理科,陕西西安710038 [2]第四军医大学唐都医院妇产科,陕西西安710038

出　　处：《现代肿瘤医学》2010年第7期1326-1328,共3页Journal of Modern Oncology

摘　　要：目的:报道1例肺内骨外骨肉瘤并探讨其临床病理学特征。方法:对1例肺内骨外骨肉瘤进行临床、组织病理学及免疫组化的观察。结果:肿瘤细胞弥漫分布,细胞核深染,异型性明显。瘤组织内可见肿瘤性骨质。免疫组化示肿瘤细胞表达Vimentin及CD99,不表达MC,CR,SM-actin,Desmin,S-100,NSE,Syn,CgA,Bcl-2,CD34,CD117,HMB45,Melanoma-pan,LCA,AACT,CD68,CK,EMA,CD15及CEA。结论:肺内骨外骨肉瘤发病率低,预后差,早期发现、早期治疗有利于提高患者的生存率。本病需要与发生于肺内伴有骨化的其它肿瘤进行鉴别诊断。Objective：To report one case of extraskeletal osteosarcoma occurring in body of pulmonary and study its clinical and pathological features. Methods： One case of extraskeletal osteosarcoma occurring in body of pulmonary was investigated by histopathologic and immunohistochemical observation. Results： Microscopically, the tumor cells were dispersed with suffusion. The nucelus were anachromasised, and their heteromorphism were obvious. Tumorous selerotin could be seen in the tumor tissue. Immunohistochemically ,the tumor cells showed positive for Vimentin and CD99, but negative for MC, CR, SM - actin, Desrnin, S - 100, NSE, Syn, CgA, Bcl - 2, CD34, CD117, HMB45, Melanoma - pan, LCA, AACT, CD68, CK, EMA, CD15 and CEA. Conclusion： Extraskeletal osteosarcoma occurring in body of pulmonary is rare and it＇s prognosis is poor. Early detection and early treatment will improve the survival rate of patients. It should be differentiated from the other ossific carcinoma occurred in the pulmonary.

关 键 词：肺 骨肉瘤 临床病理 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤]