胃癌中MGMT和EGFR表达及其意义  被引量:2

Expression and significance of MGMT and EGFR in gastric cancer and their correlation

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作  者:费建东[1] 王晓寅[2] 薄爱华[3] 吴力娟[2] 朱玉平[2] 刘志峰[2] 

机构地区:[1]河北北方学院第一附属医院普外科,张家口075029 [2]河北北方学院大学生科协,张家口075029 [3]河北北方学院实验中心电镜室,河北张家口075029

出  处:《现代肿瘤医学》2010年第7期1346-1348,共3页Journal of Modern Oncology

基  金:张家口市科技局资助项目(编号:060158)

摘  要:目的:探讨胃癌组织中O^6-甲基鸟嘌呤-DNA甲基转移酶(O^6-methylguanine-DNA-methyltransferase,MGMT)和表皮生长因子受体蛋白(epidermal growth factor receptor,EGFR)的表达情况及其临床意义。方法:采用SP免疫组织化学染色法检测69例胃癌标本中MGMT和EGFR的表达。结果:胃癌组织中MGMT和EGFR阳性率分别为52.17%(36/69)和59.42%(41/69)。MGMT和EGFR在淋巴结转移组阳性率明显高于无淋巴结转移组,差异显著(P<0.05)。癌细胞浸润深组EGFR表达增高,癌细胞分化程度低组MGMT表达增高。MGMT和EGFR的表达存在低度正相关性(r=0.2723)。结论:检测MGMT和EGFR的表达对判断胃癌患者预后及制定相应的化疗方案有指导意义。Objective:To investigate the significance of MGMT and EGFR expression in gastric cancer. Methods:The expressions of MGMT and EGFR in gastric cancer of 69 cases were examined by SP immunohistochemical method. Results:The positive rates of MGMT and EGFR were 52. 17% (36/69) and 59. 12% (41/69) in gastric cancer. Their positive expression of MGMT and EGFR were correlated with lymph node (P 〈 0.05 ). The positive rates of MGMT and EGFR in cases with lymph node metastasis were significantly higher than without ones(P 〈0.05). The expression of EGFR was higher in the group of cancer cell invasion depth. The expression of MGMT was higher in the group of lower differration degree. MGMT and EGFR were postively related(r = 0. 2723 ). Conclusion: Petecton of The expression of MGMT and EGFR in gastric cancer has guidance role to judge the degree of malignancy and to make the clinical scheme of therapy.

关 键 词:胃癌 O^6-甲基鸟嘌呤-DNA甲基转移酶 表皮生长因子受体 免疫组织化学 

分 类 号:R730.3[医药卫生—肿瘤]

 

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