膀胱癌预后与RHAMM的表达  

Prognosis of bleadder cancer and RHAMM expression

作　　者：郭启振[1] 殷波[1] 卜仁戈[1] 费翔[1] 张辉[1] 宋永胜[1] 

机构地区：[1]中国医科大学附属盛京医院泌尿外科

出　　处：《现代肿瘤医学》2010年第7期1351-1353,共3页Journal of Modern Oncology

摘　　要：目的:探讨透明质酸介导的细胞游走受体(RHAMM)在膀胱癌侵袭转移中的作用及与预后的关系。方法:采用免疫组织化学法检测膀胱癌RHAMM的表达;Western blot法检测膀胱癌RHAMM蛋白表达。结果:膀胱癌RHAMM的表达率为61.6%,随着膀胱癌进展RHAMM阳性表达有增高趋势。Western blot证实膜型RHAMM蛋白在膀胱癌有上调表达。术后复发的RHAMM阳性率为84.2%;术后无复发的RHAMM阳性率为45.8%。二者有显著差异(P<0.05)。结论:RHAMM异常表达与膀胱癌侵袭有关。RHAMM阳性者术后复发的可能性明显高于RHAMM阴性者,RHAMM可以作为判断膀胱癌复发以及预后判断的指标之一。Objective：To explore the role of receptor for HA - mediated motility （RHAMM） in the invasion and prognosis of bladder carcinoma. Methods：The expression of RHAMM in 86 cases of bladder carcinoma were studied by immunohistochemistry ; the level of RHAMM protein in bladder carcinoma was estimated by Western blot. Results： The positive expression rate of RHAMM in bladder carcinoma was 61.6%. The expression of RHAMM increased with the invasion of bladder carcinoma. Western blot suggested that the membrane - type RHAMM protein was up - regulated in bladder carcinoma with invasion. The positive rate of RHAMM in recurrence cases was 84.2%. The positive rate of RHAMM in non - recurrence cases was 45.8% ,there was difference significantly between the two groups（ P 〈 0.05 ）. Conclusion ：The abnormal expression of RHAMM is related to bladder invasion. The positive rate of RHAMM in recurrence cases is higher than that in the negative. RHAMM may be one of the markers for predicting the prognosis of bladder carcinoma.

关 键 词：膀胱肿瘤 复发 预后 透明质酸受体 

分 类 号：R730.3[医药卫生—肿瘤]