多西他赛联合替加氟和顺铂治疗晚期胃癌疗效观察  

Efficacy of combination chemotherapy with docetaxel plus cisplatin and Ftorafur in treatment of patents with advanced gastric cancer

作　　者：蒋新建[1] 明静[1] 李建蓉[1] 

机构地区：[1]四川成都市第二人民医院肿瘤科,四川成都610017

出　　处：《现代肿瘤医学》2010年第7期1367-1369,共3页Journal of Modern Oncology

摘　　要：目的:观察多西他赛联合顺铂、替加氟(DCF_t方案)治疗晚期胃癌的疗效和不良反应。方法:采用DCFt方案治疗66例晚期胃癌患者。多西他赛75m/m^2,d_1;顺铂75m/m^2,d_1;替加氟20mg/kg,静脉滴注d_(1-5)天,3周1个周期,至少2个周期。结果:66例晚期胃癌中,完全缓解(CR)0例,部分缓解(PR)36例(54.5%),稳定(SD)16例(24.2%),进展(PD)14例(21.2%)。中位肿瘤进展时间为6.1个月(3.5-11.5个月),中位总生存期为11.2个月(6.0-14.5个月)。最常见的不良反应为骨髓抑制、消化道反应及可逆性体液潴留,不良反应多为Ⅰ-Ⅱ度,无Ⅳ度不良反应发生。骨髓抑制以白细胞减少为特点,血小板减少及贫血较轻。消化道反应主要表现为恶心呕吐、腹泻便秘。无治疗相关性死亡。结论:DCFt方案是治疗晚期胃癌安全有效的化疗方案。Objective：To assess the efficacy and safety of docetaxel plus cisplatin and Ftorafur in treatment of patients with advanced gastric cancinoma. Methods： Thirty - three patients with recurrent or metastatic gastric adenocarcinoma were enrolled and received doeetaxel （75mg/m^2, d1 ） plus cisplatin （ 75mg/m^2, d1 ） followed by Ftorafur （20 mg/kg ,continous iv gtt d1-5 ）. The treatment was repeated every 3 weeks. Results： All the thirty -three patients enrolled were evaluated for response and toxicity. The overall response rate was 54.5% with complete and partial response rates of 0 and 54.5% , respectively. The median overall survival time was 11.2 months ,and the median time to progress was 6.1 months . There was no any grade - Ⅳ toxicity, but grade - Ⅲ diarrhea in 2 patients （ 6.0% ） ,grade - Ⅲ leukopenia in 3 patients （9.0%）, and grade - Ⅲ vomiting in 8 patients （ 24.0% ）. Conclusion： Combination regimen of docetaxel plus cisplatin and 5 - fluorouracil is well tolerable and shows notable activity as first - line reament in metastatic carcinoma of the stomach.

关 键 词：胃肿瘤 化学疗法 多西他赛 替加氟 顺铂 

分 类 号：R735.2[医药卫生—肿瘤]