mFOLFOX6方案治疗晚期结肠癌疗效分析  

Effect of mFOLFOX6 regimen as salvage chemotherapy for patients with advanced colon cancer

作　　者：赵征 冉飞武[2] 张晓学 雷宝霞 施常备 

机构地区：[1]陕西省肿瘤医院,陕西西安710061 [2]中国医学科学院肿瘤医院内科,北京100021

出　　处：《现代肿瘤医学》2010年第7期1374-1375,共2页Journal of Modern Oncology

摘　　要：目的:临床观察mFOLFOX6方案治疗21例晚期结肠癌的近期疗效、临床获益率和不良反应。方法:采用mFOLOFX6方案(奥沙利铂85mg/m^2静滴2小时第1天;亚叶酸钙400mg静滴2小时第1天;;5-FU400mg/m^2静冲第1天;5-FU2.4g/m^2持续静滴44小时)每两周给药。3周期化疗后观察客观缓解率、临床获益率和不良反应。结果:21例患者总有效率为47.6%。CR1例(4.8%),PR9例(42.9%),SD6例(28.6%),临床获益率为76.2%。主要不良反应是消化道反应,1-2度消化道不良反应13例(61.9%)。Ⅲ-Ⅳ度血液学毒性3例(14.3%)。结论:mFOLOFX6方案治疗晚期结肠癌是安全、有效的。Objective： To investigate the efficacy and safety of mFOLFOX6 as first - line regimen for patients with advanced colon cancer. Methods： Twenty -one patients with advanced colon cancer were treated by mFOLFOX6 regimen of 3 cycles. Results： Of the 21 patients,the overall response rate was 47.6% ,complete response rate was 4. 8% ,partial response rate was 42.9% ,clinical benefit rate was 76.2%. The major toxicity was nausea vomiting. In cidences of neutroponia of grade Ⅲ - Ⅳ was 14.3%. Conclusion： mFOLFOX6 is a safe and effective regimen in advanced colon cancer.

关 键 词：晚期结肠癌 MFOLFOX6 客观疗效 

分 类 号：R735.35[医药卫生—肿瘤]