CXCR7在疾病发生和发展中的作用  

CXCR7 in the happening and development of diseases

作　　者：胡旭民[1] 胡晓光[2] 张常华[1] 

机构地区：[1]中山大学中山医学院,广州中山510080 [2]第四军医大学第三附属医院头颈肿瘤外科,陕西西安710032

出　　处：《现代肿瘤医学》2010年第7期1455-1459,共5页Journal of Modern Oncology

基　　金：教育部2008年大学生创新性实验计划项目-中山大学第24号

摘　　要：趋化性细胞因子(chemokine)是一个蛋白质家族,由60余种结构同源、8-10kDa大小的多肽组成,负责吸引白细胞、胚胎细胞、肿瘤细胞,参与炎症反应、组织发育和肿瘤形成。近期发现一种新型受体即CXCR7,广泛分布于软骨、心脏、脑、脾、肾和多种肿瘤细胞,与CXCL12和CXCL11相互作用,促进细胞迁移、血管新生、肿瘤发生、侵袭、转移和抗细胞凋亡。本文将对其发现、结构、分布、组织表达、功能以及与癌症相关作用等方面进行综述。Chemokines is the name of a large protein family, composed of more than 60 kinds of structurally homologous polypeptide, 80 -10kDa in size, in charge of recruiting white blood cell, primodial germ cell, metastatic cell, participating in inflammatory reaction, tissue development, and tumor angiogenesis. Recently, scientists have discovered a new type of receptor, and named as CXCR7. CXCR7 extensively distributes in many parts of body, including cartilage, heart, brain, spleen, kidney, and neoplastic cell. This receptor directly reacts with CXCL12 and CXCL11 to fulfill its function, like promoting cell migration, angiogenesis, the development, invasion, metastasis, and antiapoptosis of tumor cell. This review is going to elucidate how CXCR7 has been dicovered, and the structure, expression, distribution, function, finally the relationship between tumor and it.

关 键 词：CXCR7 CXCL12 癌症 

分 类 号：R730[医药卫生—肿瘤]