腰椎病突出椎间盘组织炎症因子含量与直腿抬高的相关性研究  

The relationship between the contents of herniated tissue inflammation factor and straight leg raising level in Vertebral disease

作　　者：项菁[1] 刘君[1] 黄拥军[1] 

机构地区：[1]湖北省潜江市中心医院,433100

出　　处：《中国医学创新》2010年第18期18-19,共2页Medical Innovation of China

摘　　要：目的探讨腰椎病突出椎间盘组织中肿瘤坏死因子α和受激活调节正常T细胞表达和分泌因子表达水平及其直腿抬高的相关性。方法ELISA法检测35例腰椎病患者腰椎间盘突出物中肿瘤坏死因子Ⅸ和分泌因子表达水平，CT测量突出组织的突出指数（ST），并分别与患者的直腿抬高程度进行相关性分析。结果椎间盘突出组织中炎症因子肿瘤坏死因子α（7．03±1．22）pg／g和分泌因子水平（15．97±4．14）Pg／g分别与直腿抬高程度（32．98°±11．64°）呈明显负相关（r1=-0．563，r2=-0．864，P〈0．01）；突出物相对大小sT值（19．57±5．60）％与直腿抬高程度间（32．98°±11．64°）没有统计学相关性（r=0．19，P〉0．05）。结论腰椎病突出椎间盘的物理压迫作用并非直接病因，局部炎症因子肿瘤坏死因子α和分泌因子加剧了椎间盘的退变和炎症反应。Objective To explore TNFα and RANTES levels in Vertebral disease and the relationship between in- flammatory factors and the straight leg rate （SLR） of lumbar disc herniation （LDH） patients. Methods To detect TNFα and RANTES contents in lumbar disc herniation from 35 patiants with vertebral disease by enzyme - linked immunosorbent assay （ELISA）. The size of lumbar disc herniation were measured by computerized tomography（CT）. And the relationships between ST and SLR were studied. Results The level of TNFα （7.03 ± 1.22 ） pg/g and RANTES （ 15.97 ±4.14 ） pg/g in herniated lumbar discs were related negatively obviously with SLR（32.98°±11.64°） （r1 = -0. 563 ,r2 = -0. 864,P 〈0.01 ）. The ST of size of prominent（ 19.57 ±5.60） % had not correlation with SLR（32.98°±11.64°） （r =0.19,P 〉0.05） statistically. Conclusion Mechanical compression is not the direct cause in vertebral disease patients. The TNFα and RANTES may further contribute to the degeneration of disc and inflammatory reaction.

关 键 词：TNFΑ 分泌因子 腰椎间盘突出 直腿抬高 

分 类 号：R681.53[医药卫生—骨科学]