星形胶质细胞在脑缺血损伤中的保护作用及中药干预作用  

Protective Effect of Astrocytes in Cerebral Ischemic Injury and Chinese Herb Intervention Effect

作　　者：李慧[1] 郭虹[1] 胡利民[1] 王玉璘 

机构地区：[1]天津中医药大学中医药研究院,天津市中药药理学重点实验室,天津300193

出　　处：《辽宁中医药大学学报》2010年第7期32-33,共2页Journal of Liaoning University of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(30572348);国家科技支撑计划项目(2007BAI47B04);云南省科技计划项目(2006YX03)

摘　　要：脑缺血损伤后,通常认为主要是对神经元的损伤,但缺血的梗死区包括着其它细胞,如星形胶质细胞(astrocytes,AS)、脑微血管内皮细胞、小胶质细胞等。在脑中风损伤初期AC支持神经元的存活,所以对AS功能完整性的保护将在今后的研究中将受到进一步的重视。文章将探讨AS在脑缺血导致的神经损伤的发病机制中的基础作用及中药对其的保护作用。After ischemic injury,it is usually viewed from the opinion of neuronal loss.Yet the ischemic infarct contains other cell types,including astrocytes,brain vascular endothelial cells,and microglias.It is proposed that stroke injury is primarily a consequence of the failure of astrocytes to support the essential needs of neurons.So neuroprotective for targeting the functional integrity of astrocytes may constitute a superior strategy for future neuroprotection.There will discuss the idea that astrocytes play a fundamental role in the pathogenesis of ischemic neuronal death and Chinese Herb plays a protective effect for astrocytes.

关 键 词：星形胶质细胞 脑缺血损伤 神经保护 中药 

分 类 号：R743.34[医药卫生—神经病学与精神病学]