广州地区儿童哮喘危险因素病例对照研究  

Case-control study of the risk factors causing childhood asthma in Guangzhou City

作　　者：何启强[1,2] 杜琳[3] 黄子惠[2] 刘伟佳[3] 吴家刚[3] 蒋卓勤[4] 

机构地区：[1]武汉大学公共卫生学院,430071 [2]香港中文大学 [3]广州市疾病预防控制中心 [4]中山大学公共卫生学院

出　　处：《公共卫生与预防医学》2010年第3期23-26,共4页Journal of Public Health and Preventive Medicine

基　　金：广东省医学科研基金项目(A2008568)

摘　　要：目的探讨广州地区儿童哮喘的危险因素。方法从广州市海珠区、白云区和花都区8所小学7635名儿童中筛选出哮喘病患,按性别和年龄1∶1配对选取健康对照。通过家长问卷调查儿童家庭的社会经济特征、父母过敏和哮喘史及室内环境等因素。结果 Logistic回归分析显示,父亲、母亲有过敏史的儿童哮喘患病风险显著高于对照组,其OR值分别为5.05(95%CI:1.37～18.65)和5.38(95%CI:1.23～23.54),儿童自身过敏史与哮喘之间呈显著关联(OR=5.58,95%CI:1.53～20.36),室内新家具可显著增加儿童哮喘的患病风险(OR=6.42,95%CI:1.13～36.62)。结论父母过敏性疾病史、儿童自身过敏史和室内新家具是儿童哮喘的重要危险因素。Objective To investigate the risk factors causing childhood asthma.Methods Asthmatic children were screened from 8 primary schools in Haizhu,Baiyun,and Huadu districts of Guangzhou city.Controls were selected by gender,age,and were 1 ：1 matched. Parental questionnaires were used to collect information of children＇s home environment,socio-economic characteristics,and parental history of allergy and asthma.Results Children with parental history of allergy had significantly higher risk for asthma as compared to the controls,with OR=5.05 （95%CI：1.37-18.65） and 5.38 （95%CI：1.23-23.54） for children with allergic father and mother,respectively.Children＇s history of allergy was significantly associated with asthma （OR=5.58,95%CI：1.53-20.36）.New furniture at home significantly increased the risks for asthma （OR=6.42,95%CI：1.13-36.62）.Conclusions Parental and children＇s history of allergy and new furniture at home were important risk factors for childhood asthma.

关 键 词：哮喘 儿童 病例对照研究 

分 类 号：R562.25[医药卫生—呼吸系统]