尤瑞克林注射液对急性脑梗塞患者血浆ET及CGRP的影响研究  

Effect of Urinary Kallikrein Injection on Endothelin-1 and CGRP in Blood Plasma of Patients with Acute Cerebral Infarction

作　　者：姚明星[1] 牛玉芹[1] 赵文鹏[1] 马玉英[1] 

机构地区：[1]石河子大学医学院第一附属医院急诊科,新疆石河子832008

出　　处：《现代生物医学进展》2010年第10期1949-1950,共2页Progress in Modern Biomedicine

摘　　要：目的:研究尤瑞克林注射液对急性脑梗塞患者血浆内皮素(ET)及降钙素基因相关肽(CGRP)影响。方法:急性脑梗塞患者48例,随机分为治疗组及对照组(常规治疗)。治疗组在常规治疗的基础上加用尤瑞克林注射液。用放射免疫法检测患者治疗第1天、第7天血浆中内皮素及降钙素基因相关肽的含量,并对两组患者治疗前后进行美国国立卫生院神经功能缺损评分。结果:治疗组血浆ET水平及NIHSS均较对照组有明显下降(P<0.05),CGRP升高较对照组明显(P<0.05)。结论:尤瑞克林能显著降低急性脑梗塞患者血浆ET及升高CGRP的含量,改善血管内皮功能,降低神经功能缺损程度。Objective：To investigate the influence of the injection of Urinary Kallidinogenase on plasma endothelin（ET） and calcitonin gene-related peptide（CGRP） in patients with acute cerebral infarction.Methods：48 patients with acute cerebral infarction were randomly divided into treatment group and control group（conventional treatment）.Treatment group was treated on the basis of injection plus Urinary Kallidinogenase.Detected the plasma endothelin and calcitonin gene-related peptide by radioimmunoassay in patients after treated in the first day and the seventh days.Do the National Institutes of Health neurological deficit scores before and after treatment.Results：Compared with he control group,there are significantly decrease at the level of ET and the NIHSS（P〈0.05）.The level of CGRP increased significantly compared with the control group（P〈0.01）.Conclusion：Urinary Kallidinogenase significantly reduced level of ET and increased CGRP in patients with acute cerebral infarction.It could improve endothelial function and reduce the degree of neurological deficits.

关 键 词：尤瑞克林 脑梗塞 内皮素 降钙素基因相关肽 

分 类 号：R743.33[医药卫生—神经病学与精神病学]