半夏多糖对希罗达干预下小鼠腺癌细胞MHC-Ⅱ分子表达的增效作用  

Synergism of Pinellia Ternate Polysaccharide on Capecitabine Tablets in Inhibition of Colon Cancer in Mice

作　　者：曹书立[1] 孟宪泽[1] 魏品康[1] 

机构地区：[1]第二军医大学附属第二医院中医科,上海200003

出　　处：《现代生物医学进展》2010年第11期2034-2036,共3页Progress in Modern Biomedicine

基　　金：国家自然基金重大研究计划资助项目(NO.90709044)

摘　　要：目的:探讨半夏多糖对希罗达干预下抑制小鼠结肠腺癌的作用机制。方法:观察半夏多糖对希罗达干预下小鼠结肠腺癌的生长状态,应用流式细胞术分析瘤细胞表面MHC-Ⅱ的表达。结果:流式细胞仪检测半夏多糖对希罗达干预下可提高CD4/CD8的比值,并能增强小鼠结肠腺癌细胞表面MHC-Ⅱ表达。结论:半夏多糖可提高希罗达的抑瘤作用,其机理可能与半夏多糖提高小鼠结肠腺癌细胞表面MHC-Ⅱ表达,增强荷瘤小鼠细胞免疫的作用有关。Objective：To explore the mechanisms of Pinellia ternate polysaccharide United Capecitabine Tablets on the Inhibition of subcutaneous tumor of the mice CT-26.Methods：To investigate Pinellia ternate polysaccharide United Capecitabine Tablets on the Inhibition of subcutaneous tumor of the mice CT-26.Testing the expression of MHC-Ⅱ with Flow Cytometic instrument.Results：The expression of MHC-Ⅱ in Pinellia ternate polysaccharide United Capecitabine Tablets group compared with the Pinellia ternate polysaccharide group, Capecitabine Tablets group and NS group, the change was significantly （P0.05）.Conclusion：Pinellia ternate polysaccharide United Capecitabine Tablets can promote the expression of MHC-Ⅱ.This result can explain the high tumor inhibition rate.

关 键 词：半夏多糖 希罗达 CT26细胞 MHC-Ⅱ 流式细胞术 

分 类 号：Q95-3[生物学—动物学] R735.35[医药卫生—肿瘤]