慢性胃病患者口腔与胃内幽门螺杆菌基因型关系的研究  

The relation of genotype of helicobacter pylori in oral cavity and with that in stomach

作　　者：高静[1] 张丽[1] 靳松[1] 肖长杰[1] 李毅[1] 高德安[1] 

机构地区：[1]泰安市中心医院口腔科,山东泰安271000

出　　处：《临床口腔医学杂志》2010年第5期266-269,共4页Journal of Clinical Stomatology

基　　金：泰安市科技局基金(泰科计字[2002]9号)

摘　　要：目的:明确牙周基础治疗与口腔幽门螺杆菌(Helicobacterpylori,Hp)存在的关系。分析胃Hp与口腔Hp的基因型,以明确胃与口腔的Hp是否具有同源性。方法:选择胃Hp阳性并伴菌斑Hp阳性患者(6例)的胃黏膜、菌斑样本共10份(胃黏膜4份,菌斑6份)。对比分析其中5位患者和1位家属胃和口腔PCR产物的序列。结果:胃和口腔Hp的序列相比较,相同者1例,可能相同者1例,有1～4个碱基不同者2例。1例患者及其家属口腔中均检出Hp,两者的序列有3个不同。结论:口腔中有可能同时存在多个Hp菌株,口腔Hp与胃黏膜Hp基因型相同或基本相同,口腔Hp与胃Hp感染的复发或再感染有关。Objective：To investigate whether initial periodontal therapy may affect the presence of oral Helicobacter pylori（Hp）,and to compare the genotype of Helicobacter pylori in oral cavity and that in stomach. Method：6 patients with gastric Hp and periodontitis were enrolled in this study. DNA sequence of PCR products of 5 patients and 1 Hp infected patients relative was compared and analyzed. Result：An identical sequence of oral and stomach Hp was found in one patient, most likely identical in 1 case,difference of 1-4 bases in 2 cases.In one case and his family oral Hp showed 3 different types of DNA sequences. Conclusion：There may be multi-Hp strain existing in oral cavity.Oral colonization of Hp may imply that there is a risk of the relapses of gastric and duodental Hp infection.

关 键 词：幽门螺杆菌 牙菌斑 胃炎 基因型 聚合酶链反应 

分 类 号：R780.2[医药卫生—口腔医学] R781.4[医药卫生—临床医学]