血浆置换与血液灌流治疗重型肝炎临床对比研究  

作　　者：杨亚莉[1] 史志红[1] 赵瑞敏[1] 高荣凯[1] 韩佳佳[1] 吴瑞斌[1] 许明策[1] 张卫中[1] 樊和明[1] 

机构地区：[1]新乡市第一人民医院消化科,453000

出　　处：《中国实用医药》2010年第19期44-46,共3页China Practical Medicine

摘　　要：目的对比研究人工肝治疗中血浆置换、血液灌流的临床疗效。方法选择重型肝炎102例患者,在常规治疗的基础上随机分成两组,60例进行血浆置换治疗;42例进行血液灌流治疗,观察患者治疗前后TIB、ALB、PTA、NH3、Na、K、Crea、Urea的变化及临床症状改善。结果两组表现在TIB、ALB、PTA、NH3治疗前后有显著性差异(P<0.01);而Na+、K+、Crea、Urea治疗前后无显著性差异(P>0.05);两组治疗好转率比较:无显著性差异(P>0.05)。结论人工肝治疗中血浆置换、血液灌流的临床疗效无明显差异,主要并发症发生率有明显差异,因为血浆置换需大量血浆,治疗过程中患者总住院费用远远超过血液灌流。Objective To compare the clinical efficacy of plasmapheresis with hemoperfusion. Both plasmapheresis and hemoperfusion have been proposed as treatment strategies for severe hepatitis to reduce the risk of death. Methods We collected 102 patients suffered from severe hepatitis,and they were randomized to treatment with plasmapheresis （ 60 cases ） or hemoperfusion （ 62 cases ） . Biochemical and clinical symptoms changes were assessed before and after both plasmapheresis and hemoperfusion treatment. Results The values of Na^＋ , K ＋ , Crea, Urea were not modified by any treatment（ P 〉 0. 05 ） , While significant differences in the val- ues of TIB,ALB, PTA,NH3 were found in both groups（P 〈0. 01 ）. No significant differences were observed in the efficacy between plasmapheresis and hemoperfusion. Conclusion Plasmapheresis had the same efficacy with hemoperfusion as treatment strategy for severe hepatitis, but the incidences of chief complications were sig- nificantly different, and due to using lots of plasma in the process of plasmapheresis, making excessive cost of hospitalization, which was far beyond hemoperfusion.

关 键 词：重型肝炎 血浆置换 血液灌流 

分 类 号：R575.1[医药卫生—消化系统]