前列腺原发淋巴瘤转白血病研究  

A Study of leukemia developed from primary prostatic lymphoma

作　　者：杨丽云[1,2] 达万明[2] 赵怡雯[1] 丁琪[1] 朱平[3] 

机构地区：[1]武警总医院军人科,北京100039 [2]解放军总医院血液科,北京100853 [3]北大医院血液研究室,北京100034

出　　处：《武警医学》2010年第3期209-212,共4页Medical Journal of the Chinese People's Armed Police Force

基　　金：科技部国际科技合作重大项目(2006DFB31430);国家自然科学基金(30470939)

摘　　要：目的提高对前列腺原发淋巴瘤转白血病的认识。方法对1例前列腺原发淋巴瘤转白血病临床资料进行分析,并对其骨髓细胞做细胞免疫学、遗传学和分子生物学检查。结果患者经病理检查初诊为前列腺T细胞淋巴瘤,3个月后骨髓细胞形态学提示白血病,细胞免疫分型考虑急性双系列白血病(T-淋巴细胞、髓系白血病),染色体核型分析提示复杂变异,融合基因筛查结果SET/CAN阳性、BCR/ABL及其他融合基因阴性,IgH基因重排阳性,TCRγ、TCRδ阴性。最后确诊为急性难定系列白血病(acute leukaemias of ambiguous lineage,ALAL)。结论前列腺原发淋巴瘤罕见,该病进展快,预后差,在前列腺疾病的诊断时应考虑到它的可能并及早明确诊治。Objective To study leukemia developed from primary prostatic lymphoma. Method The clinical data of a patient with leukemia developed from primary prostatic lymphoma, and related literature were reviewed. Samples of bone marrow were analyzed by eytomorphologieal, immunological, cytogenetie and molecular biological methods. Results The patient was first diagnosed as having primary prostatic T lymphoma depending on pathology of prostatic tissue. Three months later, analysis of bone marrow tyromorphology suggested leukemia, immunophenotype test confirmed acute bilineage leukemia （T -ALL ＆ AML）, karyotyping revealed complicated karyotype. SET/CAN fusion gene was positive while BCR/ABL and the others were negative. IgH gene recombination was positive and TCRγ,TCRδ negative. The patient was finally diagnosed as having ALAL（ acute leukemia of ambiguous lineage）. Con- clusions Primary prostatic lymphoma is extremely rare, which progresses fast with poor prognosis. It should be included in the differential diagnosis of prostatic disease and treated without delay.

关 键 词：前列腺淋巴瘤 急性难定系列白血病 诊断 预后 

分 类 号：R730.2[医药卫生—肿瘤] R737.25[医药卫生—临床医学]