合并脂肪肝高血压病患者大动脉顺应性改变与胰岛素抵抗的相关性  

THE RELATION STUDY ON MAIN ARTERIAL COMPLIANCE CHANGE AND INSULIN RESISTANCE IN HYPERTENSIVE PATIENTS WITH FATTY LIVER

作　　者：张日华[1] 

机构地区：[1]深圳市宝安区松岗人民医院,广东深圳518105

出　　处：《现代医院》2010年第6期39-41,共3页Modern Hospitals

摘　　要：目的探讨合并脂肪肝的高血压病患者大动脉顺应性改变与胰岛素抵抗的关系。方法随机选择住院的高血压病患者共86例,其中伴非酒精性脂肪肝44例(A组),不伴非酒精性脂肪肝者42例(B组);另选取正常健康体检者40例作为正常对照组(C组)。所有研究对象均进行一般临床指标、血清胰岛素(INS)、脂联素(APN)和脉搏波速度(PWV)的测定。结果伴非酒精性脂肪肝患者的BMI、血压、TG、FBG值均显著高于正常健康对照组(p<0.05),但HDL-C显著低于正常健康对照组(p<0.05);不伴非酒精性脂肪肝患者的血压、TG、FBG值均显著高于正常健康对照组(p<0.05),但TC、HDL-C均显著低于正常健康对照组(p<0.05);与伴非酒精性脂肪肝患者组比较,不伴非酒精性脂肪肝患者的TC、TG值有显著性改变(p<0.05)。伴和不伴酒精性脂肪肝的高血压病患者的HOMA-IR、APN和PWV与正常健康对照组相比,在统计学上均有显著性差异(p<0.05或p<0.01);其中除HOMA-IR值显著升高外,APN和PWV值均显著降低。HOMA-IR、APN和PWV在伴与不伴酒精性脂肪肝的高血压病患者间有显著性差异(p<0.05)。结论相关性分析显示胰岛素抵抗与伴脂肪肝的高血压病患者大动脉顺应性改变有显著的关系。Objective To research the relation between main arterial compliance change and insulin resistance in hypertensive patients with fatty liver. Methods 86 cases hypertensive patients in hospital are randomly selected, 44 cases of the total with negative alcoholic fatty liver（A group）, other 42 cases without negative alcoholic fatty liver（ B group）;Another 40 cases normal healthy volunteers are selected for normal control group （ C group）. General clinical index, serum insulin （ INS）, adiponectin （APN） and pulse wave velocity （PWV） are tested in all research subjects. Results The body mass index（ BMI）, blood pressure, Triglyeeride（TG） and fasting blood glucose（FBG） in patients with negative alcoholic fatty liver are significantly higher than normal control group （p 〈 0. 05 ）, but High -density lipoprotein cholesterol （HDL - C） is significantly lower than normal control group （p 〈 0. 05 ） ; The blood pressure, Triglycofide（TG） and fasting blood glucose（FBG） in patients without negative alcoholic fatty liver are significantly higher than normal control greup（p 〈 0. 05）, however cholesterol total（TC） and HDL- C arc significantly lower than normal control greup（p 〈0. 05 ）. HOMA - IR,APN and PWV in patients with or without negative alcoholic fatty liver in comparing with norreal control group have statistically significant differenco（p 〈0. 05 orp 〈0. 01 ） ;except HOMA - IR increases notably, both APN and PWV decrease significantly. HOMA - IR,APN and PWV have significant difference in hypertensive patients between with and without alcoholic fatty liver（p 〈0. 05）. Conclusion Notable relationship between insulin resistance and ma/n artery compliance change in hypertensive patients with fatty liver are showed in correlation analysis.

关 键 词：脂肪肝 高血压病 大动脉顺应性 胰岛素抵抗 

分 类 号：R575.5[医药卫生—消化系统]