人正常胚胎和葡萄胎绒毛中纤蛋白溶酶原激活与抑制因子及其尿激酶受体的表达  

Expression of plasminogen activator and plasminogen activator inhibitor in human villi of early pregnancy and hydatidiform mole

作　　者：朱艳[1,2,3] 陈贵安[1,2,3] 冯强 刘以训[1,2,3] 

机构地区：[1]北京医科大学第三临床医学院妇产科 [2]锦州医学院附属第一医院 [3]中国科学院动物研究所计划生育生殖生物学重点实验室

出　　处：《生殖医学杂志》1999年第1期24-27,共4页Journal of Reproductive Medicine

基　　金：国家自然科学基金;计划生育生殖生物学国家重点实验室资助

摘　　要：本研究应用原位杂交技术检测人正常胚胎及葡萄胎绒毛中纤蛋白溶酶原激活与抑制因子（ｔＰＡ，ｕＰＡ，ＰＡＩ－１）及其尿激酶受体（ｕＰＡ－Ｒ）的表达。结果表明，人正常胚胎绒毛的合体滋养层和细胞滋养层细胞中均含有ｔＰＡ、ｕＰＡ、ＰＡＩ－１及ｕＰＡ－ＲｍＲＮＡ，葡萄胎绒毛中ｔＰＡ、ＰＡＩ－１及ｕＰＡ－ＲｍＲＮＡ表达明显增强。提示：（１）ＰＡ－ＰＡＩ的协同作用在维持妊娠期间正常的纤蛋白溶解可能是重要的；Objective:To determine the expression of tPA,uPA,PAI 1 and uPA R in human villi of early pregnancy and hydatidiform mole. Methods:The in situ hybridization was used to detect the mRNA of tPA,uPA,PAI 1 and uPA R in human villi of early pregnancy and hydatidiform mole. Results:The results revealed that specific staining for mRNA of tPA,uPA,PAI 1 and uPA R were observed in villous trophoblasts by in situ hybridization.tPA,PAI 1,uPA R mRNA were markedly increased in human villi of hydatidform mole. Conclusion:(1)Coordinative regulation of PA and PAI expression could be important in maintaining normal fibrinolysis during pregnancy;(2)the balance between PAs and PAI 1 may play a key role in the development of human hydatidiform mole

关 键 词：绒毛 葡萄胎 纤溶酶原激活剂 纤溶酶原灭活剂 

分 类 号：R737.330.2[医药卫生—肿瘤] R714.1[医药卫生—临床医学]