参射汤配合放射治疗鼻咽癌研究(附411例临床观察)  

Phase Ⅲ study on 411 nasopharyngeal carcinoma patients treated with combined Chinese medicine and radiotherapy

作　　者：吴敬亮[1] 许映卿[1] 李伟雄[1] 王丁[1] 姚敏元[1] 

机构地区：[1]广东省人民医院放射治疗科

出　　处：《中华放射肿瘤学杂志》1999年第1期32-34,共3页Chinese Journal of Radiation Oncology

基　　金：广东省中医药管理局资助

摘　　要：目的观察参射汤（中药合剂）配合放射治疗鼻咽癌，能否改善患者在放射治疗中的副反应并提高患者的远期生存率。方法１９８４年６月～１９９３年６月用参射汤配合放射治疗鼻咽癌研究，参射汤＋放射治疗３５１例（Ａ组），单纯放射治疗６０例（Ｂ组）。结果随访结果分析，Ａ组和Ｂ组病例口腔粘膜出现白膜反应分别为８．３％（２９／３５１）和３１．７％（１９／６０）；粘膜溃疡分别为２．０％（７／３５１）和４８．３％（２９／６０）；吃干饭分别为９３．２％（３２７／３５１）和１０．０％（６／６０）；吃半流分别为５．１％（１８／３５１）和３８．３％（２３／６０）；吃全流分别为１．７％（６／３５１）和５１．７％（３１／６０）。５年生存率Ａ组和Ｂ组分别为６６．７％（２３４／３５１）和４８．３％（２９／６０）。２个组比较差异有显著意义（Ｐ＜０．０１）。结论研究显示用参射汤配合放射治疗鼻咽癌，能降低患者放射治疗反应，提高生存率并无远期毒性反应。Objective To improve results of radiotherapy of nasopharyngeal carcinoma (NPC), combination of Chinese medicine and radiotherapy was tested.Methods 351 NPC patients treated with combination of Chinese medicine and radiotherapy (Group A), and 60 patients with radiotherapy alone (Group B) were admitted from June 1984 to June 1993. The clinical statuses were comparable in Groups A and B.Results Follow up studies of Groups A and B showed that the frequencies of oral pseudomembranous reaction were 8.3% (29/351) and 31.7% (19/60), ulceration 2.0% (7/351) and 48.3% (29/60). The diet intake in Groups A and B were regular meal 93.2% (327/351) and 10.0% (6/60), semi liquid 5.1% (18/351) and 38.3% (23/60),liquid 1.7% (6/351) and 51.7% (31/60), respectively. The 5 year survival rates of Groups A and B were 66.7% (234/351) and 48.3% (29/60) (P<0.01).Conclusions Our phase Ⅲ study shows that combination treatment of Chinese medicine and radiotherapy is able to render the reactions milder and raise the 5 year survival of radiotherapy without any remote toxic effects.

关 键 词：鼻咽肿瘤 放射疗法 中西医结合治疗 

分 类 号：R739.630.5[医药卫生—肿瘤] R730.59[医药卫生—临床医学]