宫颈癌细胞增殖及凋亡与bcl-2表达的研究  

The Study of Cell Proliferation and Apoptosis with bcl 2 Expression in Cervical Carcinomas

作　　者：蒋玉萍[1] 马淑芬[1] 高福禄[1] 朱志洁[1] 文顺金[1] 赵春芳[1] 张杰英[1] 

机构地区：[1]河北医科大学附属第二医院妇产科

出　　处：《解剖科学进展》1999年第1期61-65,共5页Progress of Anatomical Sciences

摘　　要：本研究旨在探求宫颈癌变中细胞增殖和细胞凋亡的变化规律，以及凋亡出现频率与ｂｃｌ－２癌蛋白的关系。结果发现宫颈癌组织的增殖指数（ＰＩ）和凋亡指数（ＡＩ）明显高于正常宫颈组织和宫颈不典型增生组织（Ｐ＜０．０１），而ＡＩ／ＰＩ显著低于两者（Ｐ＜０．０１）。ｂｃｌ－２癌蛋白常见于正常宫颈上皮和不典型增生上皮的基底细胞层，宫颈癌组织中其表达随临床期别升高呈下降趋势，ｂｃｌ－２阳性组的ＡＩ与阴性组无显著差异。证实宫颈癌变是细胞无限增殖，凋亡异常被抑制的结果。ｂｃｌ－２是宫颈癌变的早期特征。The aims of study is to determine the roles of cell proliferation and apoptosis in cervical carcinogenesis and apoptosis and relations between apoptotic frenquency and bcl 2 oncoprotein. Our data indicated both proliferation index(PI) and apoptotic index(AI) in cervical carcinomas were significantly higer than those of normal cervix and cervical dysplasia (P<0.01).Furthermore, the ratio of AI/PI in carcinomas was significantly lower than that in normal cervix and cervical dysplasia (P<0.01).Bcl 2 oncoprotein was always expressed in basal layer of normal cervix and dysplasia, it was trend that bcl 2 expression decreased with increasing clinical stages. There was no significant difference in AI between bcl 2 positive tumors and negative ones (P>0.05). Cervical carcinogenesis is the results of the abnormal augmentation of proliferation activity and the inhibition of apoptosis. Our data indicate the bcl 2 expression is characteristric of the early phase of cervical carcinogenesis but is not only factor in this process.

关 键 词：增殖细胞核抗原 细胞凋亡 BCL-2 宫颈癌 

分 类 号：R737.330.2[医药卫生—肿瘤]