TGF-β1与EGFR在子宫内膜癌患者内膜组织中的表达及意义  

The expression and meaning of TGF-β1 and EGFR in endometrial carcinoma

作　　者：王卓然[1] 宋巍[1] 孙壮状[1] 范佳颖[1] 关咏梅[1] 

机构地区：[1]哈尔滨医科大学附属第一医院生殖医学科,黑龙江150001

出　　处：《中国优生与遗传杂志》2010年第7期21-22,32,共3页Chinese Journal of Birth Health & Heredity

摘　　要：目的检测转化生长因子-β1(transforming growth factor beta 1,TGF-β1)以及表皮生长因子受体(epider-mal growth factor receptor,EGFR)在子宫内膜癌患者内膜组织中的表达,探讨两者在子宫内膜癌发生发展中的作用,为分子靶向治疗提供理论依据。方法采用免疫组织化学方法检测子宫内膜癌组(26例)及正常子宫内膜组(26例)中TGF-β1和EGFR的表达情况。结果 TGF-β1在子宫内膜癌组中的表达显著高于正常子宫内膜组(P<0.05);EGFR在子宫内膜癌组中的表达也显著高于正常子宫内膜组(P<0.05)。结论 TGF-β1及EGFR的异常表达可能与子宫内膜癌的发生发展有关。Objective：To study the expression of transforming growth factor beta 1 （TGF-β1） and epidermal growth factor receptor （EGFR） in endometrial carcinoma,to explore the role of TGF-β1 and EGFR in the pathogenesis of endometrial carcinoma and provide a theoretical basis for molecular targeted therapy. Methods：Immunohistochemical streptavidin peroxidase method wasused to detect the expression of TGF-β1 and EGFR in the endometrial carcinoma of26 cases and in the normal endometrium of 26 ca-ses. Results：The expression of TGF-β1 in endometrial carcinoma were significantly higher than that in normal endometrium （P〈0.05）; The expression of EGFR in endometrial carcinoma were significantly higher than that in normal endometrium （P〈0.05）.Conclusion：The abnormal expression of TGF-β1 and EGFR might be correlation with the pathogenesis of endometrial carcinoma.

关 键 词：子宫内膜癌 转化生长因子-Β1 表皮生长因子受体 免疫组织化学 分子靶向治疗 

分 类 号：R737.33[医药卫生—肿瘤]