632例皮肤恶性肿瘤及癌前病变临床分析  

Skin cancer and precancerous skin lesions： clinical analysis of 632 cases

作　　者：黄远深[1] 李航[1] 涂平[1] 陈喜雪[1] 杨淑霞[1] 武玲慎[1] 赵俊郁[1] 李雪迎[2] 

机构地区：[1]北京大学第一医院皮肤性病科,100034 [2]北京大学第一医院统计室,100034

出　　处：《中华皮肤科杂志》2010年第7期452-454,共3页Chinese Journal of Dermatology

基　　金：卫生部部属（管）医院临床学科重点项目资助（卫规财函[2007]353号）

摘　　要：目的 探讨皮肤恶性肿瘤的临床特点.方法 回顾2005-2008年病理诊断皮肤恶性肿瘤及癌前病变的病例资料,重新阅片确认肿瘤诊断和病理亚型分型后,利用统计软件进行分析.结果 基底细胞癌及原位和侵袭性鳞状细胞癌最多见,分别占总病例数的29.3%及24.2%.在所研究病例中,〉60岁发病者占55.4%,35～59岁发病比例达到34.3%,青少年患者比例为10.3%.Paget病临床诊断与病理诊断的符合率接近90.0%,但其他常见皮肤恶性肿瘤及癌前病变临床与病理的符合率仅在70.0%左右.结论 在皮肤恶性肿瘤及癌前病变中,头面部皮肤肿瘤及癌前病变病例明显多于其他部位.中青年患者不仅在皮肤淋巴瘤相关肿瘤病例中多见,而且在上皮来源的皮肤恶性肿瘤及黑素瘤病例中占有显著比例.Objective To investigate the clinical features of skin cancer.Methods Clinical data of skin cancer and precancerous skin lesions confirmed pathologically from 2005 to 2008 in Peking University First Hospital were retrospectively analyzed by using statistical methods.Results A total of 632 cases of skin cancer and precancerous skin lesions were studied.The most common skin cancer was basal cell carcinoma and squamous cell carcinoma （invasive and in situ） which accounted for 29.3%and 24.2%,respectively.The average age at onset was older than 60 years in 55.4%of the patients,between 35 and 59 years in 34.3%,younger than 35 years in 10.3%.The concordance between clinical and pathological diagnosis reached nearly 90.O%for Paget＇s disease,70.0% for other common skin cancer and precancerous skin lesions.Conclusions Skin cancer and precancerous skin lesions have a predilection for scalp and face.Patients aged from 35 to 59 years account for a significant proportion not only in cutaneous lymphoma but also in melanoma and epithelium-derived nonmelanoma skin cancer.

关 键 词：皮肤肿瘤 癌前状态 回顾性研究 

分 类 号：R739.5[医药卫生—肿瘤]