梅毒患者肿瘤坏死因子-α基因308位点多态性研究  

Tumor necrosis factor-α gene -308G/A single nucleotide polymorphism in patients with syphilis

作　　者：刘春[1] 齐淑贞[1] 王千秋[1] 

机构地区：[1]中国医学科学院北京协和医学院皮肤病研究所,南京210042

出　　处：《中华皮肤科杂志》2010年第7期501-503,共3页Chinese Journal of Dermatology

基　　金：国家自然科学基金（30771930）

摘　　要：目的 研究肿瘤坏死因子-α（TNF-α）基因-308位点G/A单核苷酸多态性与梅毒遗传易感性之间是否存在关联.方法 应用实时荧光定量PCR技术检测56例早期显性梅毒患者、38例早期潜伏梅毒患者和102例正常人对照组TNF-α基因308位点G/A单核苷酸多态性.结果 早期梅毒组TNF-α-308位点G、A等位基因的分布频率分别为0.926、0.074,正常人对照组分别为0.941、0.059,两组比较差异均无统计学意义（P值均〉0.05）;显性梅毒组TNF-α-308位点G、A等位基因的分布频率分别为0.929、0.071,潜伏梅毒组分别为0.921、0.079,两组比较差异无统计学意义（P值均〉0.05）.结论 TNF-α基因308位点G/A单核苷酸多态性与梅毒遗传易感性可能无显著相关.Objective To explore the association of tumor necrosis factor（TNF）-α gene-308G/A single nucleotide polymorphism with susceptibility to syphilis.Methods The study includes 56 patients with early symptomatic syphilis,38 with eady latent syphilis,and 102 normal human controls.The-308G/A single nucleotide polymorphism of TNF-α gene was detected in all subjects by real-time fluorescent quantitative PCR.Results The frequency of TNF-α-308 G and A allele was 0.926 and 0.074 in patients with early syphilis,0.941 and 0.059 in the controls,0.929 and 0.071 in patients with early symptomatic syphihs,0.921 and 0.079 in patients with early latent syphilis.No significant difference was found between patients with early syphilis and the controls or between patients with early symptomatic syphilis and those with early latent syphilis in the frequency of either allele （MG） at-308 position of TNF-α gene（all P〉0.05）.Conclusion There seems to be no evidence for association between TNF-α gene-308G/A single nucleotide polymorphism and susceptibility to syphilis.

关 键 词：梅毒 肿瘤坏死因子Α 多态性 单核苷酸 疾病遗传易感性 

分 类 号：R759.1[医药卫生—皮肤病学与性病学]