白细胞介素-8单核苷酸多态性与子宫颈癌易感性的关系  

Correlation between single nucleotide polymorphisms of IL-8 and susceptibility to cervical cancer

作　　者：张莉[1] 吴素慧[1] 尚海霞[1] 唐世倩[1] 林维凤[1] 

机构地区：[1]山西医科大学第一医院妇产科,太原030001

出　　处：《肿瘤研究与临床》2010年第6期404-405,409,共3页Cancer Research and Clinic

基　　金：山西省自然科学基金（2006011121）;山西省科技攻关项目（2007031091-6）

摘　　要：目的 探讨白细胞介素（IL）-8-251A/T单核苷酸多态性与子宫颈癌发病的相关性.方法 应用四引物扩增受阻突变体系-聚合酶链反应技术（Tetra-primer ARMS-PCR）分析217例子宫颈癌患者和190例健康对照者外周血IL-8-251A/T位点的基因多态性,用Logistic回归模型计算各种基因型的子宫颈癌风险（OR）及其95%可信区间.结果 IL-8-251A/T单核苷酸多态性三种基因型在病例组分别为18.89%、53.46%、27.65%,对照组则分别为35.79%、44.21%、20.00%,两组差异有统计学意义（P〈0.05） TT基因型及T等位基因的子宫颈癌发病OR分别为2.619、1.639.结论 IL-8.251A/T基因多态性可能是子宫颈癌发病的遗传易感因素.Objective To investigate the relationship between single nucleotide polymorphisms of IL-8-251 A/T and the occurrence of cervical cancer.Methods A retrospective case-control study design Was applied for the present study.The cage group included peripheral blood samples from 217 cervical cancer patients and peripheral blood samples from 190 healthy women.Tetra-primer amplification refractory mutation system polymerase chain reaction Was used to analyze the genotype distribution and allele frequency of IL-8-251 A/T.Results It-8-251 MT gene polymowhisms included three genotypes：AA,AT and TT.Proportions of genotypes were 18.89%,53.46%,27.65%in cage group,respectively and were 35.79%,44.21%,20.00%in control group,respectively.There was statistical significance（P〈0.05）between the case group and the control group.The risk of genotype TT and T allele for cervical cancer Wag 2.619 and 1.639.respectively.Conclusion IL-8-25 1 A/T may be a genetic susceptibility factors for cervical cancer.

关 键 词：子宫颈肿瘤 白细胞介素-8 多态性 单核苷酸 

分 类 号：R737.33[医药卫生—肿瘤]