大肠癌与饮食相关危险因素病例对照研究  

Matched case-control study on dietary risk factors of colorectal cancer

作　　者：安庆玉[1] 李晓枫[2] 高晓虹[2] 马莉[2] 程然[2] 

机构地区：[1]大连市疾病预防控制中心传染病与地方病防制所,116027 [2]大连医科大学流行病学教研室

出　　处：《中国公共卫生》2010年第7期892-893,共2页Chinese Journal of Public Health

摘　　要：目的探讨与大肠癌发病相关的饮食危险因素,为大肠癌的防治提供科学依据。方法采用配对病例对照研究的方法 ,选择2007-2008年辽宁省大连市新发大肠癌患者200例及同期住院符合配对条件的对照200例,使用统一设计的调查表进行问卷调查;应用SPSS13.0软件中的COX回归模型进行单因素和多因素条件Logistic回归分析。结果多因素分析结果显示,10年前较多食用腌制食品(OR=2.154,95%CI=1.554～2.986)、动物肝脏(OR=6.553,95%CI=1.810～23.721)、煎、炸、烤制食品(OR=2.689,95%CI=1.387～5.214)是大肠癌相关饮食危险因素,而10年前较多食用新鲜蔬菜(OR=0.505,95%CI=0.310～0.821)、鸡肉(OR=0.490,95%CI=0.273～0.879)及生蒜(OR=0.467,95%CI=0.278～0.783)是大肠癌的保护因素;单因素分析结果表明,2组10年前在摄入贝类、豆类及其制品的食用频次方面差异有统计学意义。结论大连市大肠癌的发病主要与10年前较少摄入新鲜蔬菜、生蒜、鸡肉及过多摄入腌制食品、动物肝脏、煎、炸、烤制食品等因素密切相关。Objective To investigate dietary risk factors of colorectal cancer and to provide scientific basis for prevention of colorectal cancer.Methods A matched case-control study was carried out in Dalian city including 200 colorectal cancer cases and 200 controls.Cases were chosen from inpatients with colorectal cancer diagnosed in the latest one year.The controls were chosen from inpatients of the same hospital and hospitalized in the same period.The data were analyzed with univariate analysis and multivariate conditional logistic regression.Results Conditional logistic regression showed that taking much pickled food（odds ratio[OR]= 2.154,95% confidence interval[CI]= 1.554-2.986,animal liver（OR = 6.553,95% CI = 1.810-23.721）,fried and baked meat ten years ago（OR = 2.689,95% CI = 1.387-5.214） were the risk factors of colorectal cancer,and taking much fresh vegetables（OR = 0.505,95% CI = 0.310-0.821）,chicken meat（OR = 0.490,95% CI = 0.273-0.879）,and garlic（OR = 0.467,95% CI = 0.278-0.783）were the protective factors of colorectal cancer.One way analysis showed that there was a statistically significant relationship between the intake of seashell,bean products ten years ago and colorectal cancer.Conclusion The incidence of colorectal cancer in Dalian city was related to intaking less fresh vegetable,garlic and chicken meat ten years ago and intaking much more pickled food,animal liver,fried and baked meat.

关 键 词：大肠癌 饮食因素 配对病例对照研究 

分 类 号：R735[医药卫生—肿瘤]