格林-巴利综合征临床、C-jejuni和GM_1抗体的相关性  

Relationship between Clinical Features and Antiboides to C-jejuni, GM_1 in Gullan-Barre Syndrome

作　　者：忻琪珺[1] 程源深[1] 

机构地区：[1]浙江医科大学附属二院神经内科,310009

出　　处：《中国临床神经科学》1999年第1期4-9,共6页Chinese Journal of Clinical Neurosciences

摘　　要：目的:格林-巴利综合征(GBS)病因及发病机制探讨。方法:ELISA法测定49例GBS病人血清抗空肠弯曲菌抗体(Cj-Ab)及GM_1-IgG抗体,并与临床严重程度、预后、电生理进行相关分析。结果:GBS组血清Cj-IgA、IgG,GM_1-IgG阳性率与对照组存在显著差异,而GBS组血清Cj抗体、GM_1抗体与临床严重程度、预后及电生理均无相关性。结论:Cj近期感染与GBS发病相关;GBS病人血清GM_1-IgG亦有显著升高,但与Cj感染无关,可能只是一种神经损害后继发免疫改变,反对Yuki关于Cj感染后自身免疫引起GBS学说。ve: Study on etiology and pathogenesis of Guillain-Barre Syndrome. Methods: ELISA assay was adopted to investigate antibodies of Campylobacter jejuni antigens and glycoconjugates GM1 in the serum of GBS patients. Interelate analysis was made between those antibodies with clinical severity, prognosis and electrophysiology in GBS. Result: Significant difference was found in positive rate of Cj-IgA、Cj-IgG and GM1-IgG between GBS group and the controls, but there was no relation among Cj antibodies, GM1 antibody and clinical severity, prognosis, electrophysiology. Conclusion: There existed relationship between recent Cj infection and GBS, but no relation between GM1-Ab and Cj infection was found. Positive rate of GM1-Ab was higher in GBS group, suggested that secondary immune reaction after neural demage propably exist. We opposed Yuki's theory of pathogenesis of GBS.

关 键 词：G-B综合征 空肠弯曲菌 GM1抗体 病理 

分 类 号：R745.430.2[医药卫生—神经病学与精神病学]