骨转移性癌患者血清PINP、BALP检测的临床意义  

Clinical Application of Determination of Serum PINP and BALP Contents in Cancer Patients with Bone Metastases for Diagnosis

作　　者：王波[1,2] 杨欢[2] 庞琴霞[1] 邰国梅[1] 张军宁[1] 

机构地区：[1]苏州大学附属第一医院放疗科,江苏苏州215006 [2]苏州大学附属第二医院检验科,江苏苏州215004

出　　处：《中国血液流变学杂志》2010年第2期256-258,共3页Chinese Journal of Hemorheology

摘　　要：目的 探讨血清PINP、BALP在骨转移癌诊断中的临床价值.方法 依据骨显像和其他影像手段将80例恶性肿瘤患者分为无骨转移组（对照组）39例和骨转移组41例,采用 Soloway分级标准,将骨转移组患者再分为三个亚组进行研究.A 组：骨转移灶〈6个,20例;B组：骨转移灶6～20个,12例;C组：骨转移灶〉20个或超级显像,9例.所有患者空腹抽取静脉血采用ELISA法测定Ⅰ型前胶原氨基端前肽（PINP）、骨特异性碱性磷酸酶（BALP）的数值.分析血清PINP、BALP水平在各级骨转移组间的变化情况,判断PINP、BALP与骨转移程度之间的相关性及其彼此之间的相关性.结果 （1）骨转移癌患者血清PINP、BALP水平较对照组均有升高趋势,血清BALP水平较对照组升高有差异（ P〈0.05）.（2） A、B、C三组血清PINP水平依次递增,组与组之间比较有差异（ P〈0.05）;血清BALP水平在A、B、C三组总体有依次递增趋势,C组与A、B两组有差异 （P〈0.05）.（3）PINP水平与骨转移灶数目有一定相关性（ r=0.3662,P〈0.05）.结论 血清PINP、 BALP水平的检测都能反映骨转移患者的病情变化 .Objective To study the clinical value of serum procollagen I N-terminal propeptide（PINP） and bone-specific alkaline phosphatase（BALP）contents in cancer patients with bone metastases for diagnosis .Methods Serum PINP and BALP contents were measured with ELISA in 41 patients with bone metastases and 39 controls without bone metastases.The patients with bone metastases consisted of：① group A,less than 6 metastases loci, n=20;②group B,6 - 20 foci,n= 12;③group C,over 20 foci,n=9.The comparison of bone turnovers among patients with different bone loads were analyzed. Results （l）Serum BALP contents was greater in patients with bone metastases than without bone metastases（P〈0.05）.（2） With the increase of the extent of bone metastases, serum PINP contents elevated,there were difference among each grade（P〈0.05）.BALP elevated,there were difference between Group C and Group A ,B（P〈0.05）.（3） Levels of PINP were correlated well to the number of foci（P〈0.05）.Conclusion The determinations of serum PINP and BALP could reflect the clinical status of metastases size.

关 键 词：PINP BALP 骨转移 癌 

分 类 号：R730.4[医药卫生—肿瘤]