环孢素联合糖皮质激素治疗Vogt-小柳原田病的临床研究  

Clinical Study of CSA Combined with Glucocorticoid in the Treatment of Vogt-Koyanagi-harada Disease

作　　者：刘红[1] 张万臣 谷万章[1] 

机构地区：[1]中航工业哈尔滨二四二医院眼科,黑龙江哈尔滨150066 [2]大庆市第五医院眼科,黑龙江大庆163000

出　　处：《航空航天医药》2010年第6期871-873,共3页Aerospace Medicine

摘　　要：目的:探讨环孢素联合糖皮质激素治疗VKH病的临床疗效。方法:选择07年1月至08年2月哈尔滨242医院眼科眼底病病房VKH病患者36例(72只眼),患病年龄18～60岁,平均39.53岁;男21例,女15例;视力4.0-4.1有29只眼,4.2-4.3有15只眼,≥4.4有28只眼;随机分为对照组和治疗组,前者20例(40只眼)应用环孢素联合糖皮质激素治疗,后者16例(32只眼)常规应用糖皮质激素的治疗,对两组患者治疗前和治疗后一个月的视力、多焦视网膜电图及眼底荧光血管造影等方面的变化情况进行比较。结果:(1)视力方面,治疗组治疗前后视力比较,差异有统计学意义(p<0.01),对照组治疗前后比较,差异有统计学意义(p<0.05),治疗组与对照组治疗后视力比较,差异有统计学意义(p<0.05),治疗组优于对照组;(2)多焦视网膜电图(mfERG):两组治疗前后Pl波振幅密度增加,潜伏时缩短,差异均有统计学意义(p<0.05),治疗后治疗组与对照组P1波振幅密度和潜伏时变化比较,差异有统计学意义(p<0.05),治疗组优于对照组;(3)眼底荧光血管造影方面:两组视网膜荧光素渗漏改善情况比较,差异有统计学意义(p<0.05),治疗组优于对照组。结论:环孢素联合糖皮质激素治疗VKH病可取得良好疗效。Objective：To observe the therapeutic efficacy of CSA with glucocorticoid treated the Vogt-Koyanagi harada disease.Methods：Clinically collected the 36 patients（72eyes） diagnosed as the Vogt-Koyanagi-Harada disease,the age of patients from 18 to 60 average 39.53years old;Male21 woman 15examples ;the sight of 29 eyes between4.0 and 4.1 4.2 ～ 4.3 have15 eyes.≥4.4 have28 eyes.patients are divided into contrasted group and treating group at random,the treating group have 20 patients（40eyes） treated by the CSA combined with glucocorticoid,observed group have 16 patients（32eyes） treated by the glucocorticoid only;these eyes are checked respectively by the vision,Mf-ERG,FFAbefore and after treating.All of the data are analyzed by the statistics,then evaluate the clinical effect.Results：（1）The sight aspect,the treating group was significant diffience between the before and after treating（P 0.01）;the contrasted group was significant diffience between the before and after treating（P 0.05）;after treating,the vision of two groups have both improvement,the treating group was superior to the contrasted Group（P 0.05）;（2） For mf-ERG,the absolute value of responding density of wave p1 of two groups decurtate,they had the statistical significance（P 0.05）;after treating there was significant difference between two groups（P 0.05）.（3）For FFA,after treating,compared to the improvement of leakage of fluorscein had the statistical significance（P 0.05）.Conclusions：CSA with glucocorticoid has more superior curative effect than glucocorticoid only on treating the Vogt-Koyanagi-Harada disease.

关 键 词：VKH病 糖皮质激素 环孢素 荧光血管血管造影 多焦视网膜电图 

分 类 号：R77[医药卫生—眼科]