过敏性紫癜患者红细胞免疫功能与NK细胞活性的变化  

Changs of red cell immune function and natural killer cells in HSP

作　　者：赵绵松[1,2] 石岩[1,2] 秦桂秀 

机构地区：[1]山西医科大学第一医院 [2]山西省儿童医院

出　　处：《中华风湿病学杂志》1999年第1期44-45,共2页Chinese Journal of Rheumatology

摘　　要：目的探讨红细胞免疫及天然杀伤细胞（ＮＫＣ）在过敏性紫癜（ＨＳＰ）发病中的可能作用。方法红细胞免疫采用郭峰法测定２２例ＨＳＰ患者，红细胞Ｃ３ｂ受体花环率（ＲＢＣＣ３ｂＲＲ），与免疫复合物受体花环率（ＲＢＣＩＣＲ），流式细胞仪与单克隆抗体（ＣＤ１６）测定ＮＫ细胞的活性。并与２０名正常体检儿童对照。结果ＨＳＰ患者ＲＢＣＣ３ｂＲＲ及ＮＫＣ活性低于正常对照组（Ｐ＜００１），ＲＢＣＩＣＲ高于正常对照组（Ｐ＜００１），ＮＫ细胞与ＲＢＣＣ３ｂＲＲ呈正相关，ｒ＝０９５６，而ＲＢＣＣ３ｂＲＲ与ＲＢＣＩＣＲ呈负相关，ｒ＝１。结论红细胞与ＮＫ细胞可能参与了ＨＳＰ的发病过程，并在ＨＳＰ的病理过程中发挥着重要作用。Objective To investigate the possible role of red cell c3b reseptor rosette (RBC C3bRR)and red blood cell immune complex rosette(RBC ICR) in the devolopment of HSP.Methods RBC c3bRR and RBC ICR was tested with Guo Feng technique and NKC with flow cytometry in 22 HSP patients and 20 healthy individuals.Results RBC C3bRR and NKC were decreaed significantly,but RBC ICR were elevated in HSP patients,as compared with healthy group ( P <0 01).NKC correlated positively with RBC C3bRR( r =0 956, P <0 001).Conclusion RBC immune and NKC may play an important role in the pathogenesis of HSP.

关 键 词：过敏性紫癜 天然杀伤细胞 红细胞免疫 

分 类 号：R556.403[医药卫生—血液循环系统疾病]