空腹胃液中挥发性亚硝胺含量与胃癌和萎缩性胃炎关系的研究  

DETERMINATION OF VOLATILE NITROSAMINES IN FASTING GASTRIC JUICE AND STUDY OF THEIR RELATIONSHIP WITH GASTRIC CANCER AND ATROPHIC GASTRITIS

作　　者：施一江[1,2] 黎钧耀[1,2] 李茂生 王理伟 耿长灰[1,2] 王国清 秦德兴 邹小农[1,2] 

机构地区：[1]中国医学科学院中国协和医科大学肿瘤医院肿瘤研究所 [2]江苏省扬中县人民医院

出　　处：《中国癌症杂志》1999年第1期1-3,共3页China Oncology

摘　　要：目的验证胃癌的亚硝胺病因假说。方法在江苏省扬中县，对经过胃镜和病理确认的胃癌１０２例、萎缩性胃炎９０例、正常及浅表性胃炎１４６例，用气相色谱热能分析仪的方法，测定比较其胃液挥发性亚硝胺的含量，并用试纸法测定了胃液的ｐＨ值。结果胃液的ｐＨ值随胃粘膜的病变严重程度而上升。人群亚硝胺的总检出率在各组都很高，胃癌组、萎缩性胃炎组、正常及浅表性胃炎组的亚硝胺的总检出率分别为９９０２％、９８８９％、９８６３％。组间无显著差异（Ｐ＞００５）。但各种亚硝胺，如二甲基亚硝胺、二乙基亚硝胺、甲基卞基亚硝安、亚硝基吡咯烷、亚硝基哌啶的检出率，胃癌组、萎缩性胃炎组都比正常浅表性胃炎组有增高趋势。这种升高趋势从亚硝胺含量的比较上则更为显著。胃癌组和萎缩性胃炎组二甲基亚硝胺、二乙基亚硝胺含量及亚硝胺总量都比正常和浅表性胃炎组有显著增高（Ｐ＜００１）。结论亚硝胺可能与胃癌和萎缩性胃炎的发生有一定的关系。PURPOSE To further investigate the ralationship between volatile nitrosamine and gastric cancer.METHODS Concentration of volatile nitrosamine in the gastric juice was determined by gas chromatography combind with thermal energy analyser method and pH value of their gastric juice were tested by indicator paper.All subjects with gastric cancer.atrophic gastritis,superficial gastritis and normal controls were screened by endoscopy and pathological review.RESULTS pH value of gastric juice was higher among those with atrophic gastritis and gastric cancer.The positive rate for all nitrosamine tested was high among all subjects,99.02%,98.89% and 98.63% for gastric cancer,atrophic gastritis and normal or superficial gastritis respectively and no significant difference was found( P >0.05). But there was always an upward trand of positive rate of nitrosamine when compared for every nitrosamine from normal or superfical group to atrophic gastritis group and to gastric cancer group.This trand remained so or became even more obvious when the concentrations of nitrosamine were compared.CONCLUSION Nitrosamine may be responsible for both atrophic gastritis and gastric cancer.

关 键 词：胃癌 萎缩性胃炎 亚硝胺 胃液 病理学 

分 类 号：R735.202[医药卫生—肿瘤] R573.320.2[医药卫生—临床医学]