单唾液酸四己糖神经节苷脂相关格林巴利综合征  

Guillain-Barre syndrome associated with monosialotetrahexosylganglioside

作　　者：唐东蕾[1,2] 刘芳[1] 孙庆利[3] 徐迎胜[3] 

机构地区：[1]北京大学第三医院药剂科,北京100191 [2]东莞市人民医院药剂科,广东东莞523000 [3]北京大学第三医院神经科,北京100191

出　　处：《药物不良反应杂志》2010年第3期208-209,共2页Adverse Drug Reactions Journal

摘　　要：1例52岁男性患者,因外伤给予单唾液酸四己糖神经节苷脂40mg加入0.9%氯化钠注射液250mL,1次/d静脉滴注;天麻素注射液200mg,2次/d肌内注射,共治疗14d。用药8d后患者突然出现四肢酸痛,伴肢体无力。10d后四肢无力加重,无法直立,伴有多汗。查体示四肢肌力、肌张力降低,腱反射未引出。脑脊液检查显示蛋白-细胞分离。给予营养周围神经、脱水、改善脑细胞代谢治疗,并未再使用单唾液酸四己糖神经节苷脂和天麻素注射液。15d后病情好转。A 52-year-old man with trauma received an IV infusion of monosialotetrahexosylganglioside 40 mg dissolved in 0. 9% sodium chloride 250 mL once daily and IM gastrodine 200 mg twice daily for 14 days. Eight days later,the patient suddenly developed aching pain in limbs with weakness. Ten days later,he experienced worsened weakness in extremities and was unable to stand upright accompanied by polyhidrosis. Physical examinations showed decreased myodynamia and muscular tension in limbs and tendon reflexes were absent. Cerebrospinal fluid testing revealed albuminocytological dissociation. He received multiple treatments,including peripheral nerve nourishment,dehydration,and improving brain cell metabolism. Monosialotetrahexosylganglioside and gastrodine were not readministered. His conditions relieved after 15 days.

关 键 词：单唾液酸四己糖神经节苷脂 不良反应 格林巴利综合征 

分 类 号：R745.43[医药卫生—神经病学与精神病学]