Effect of Moxibustion on IL-1β and IL-2 in Rat Models of Rheumatoid Arthritis  

作　　者：胡玲 Dirckinck-Holmfeld Lars 宋小鸽 唐照亮 蔡荣林 何璐 罗磊 

机构地区：[1]Research Institute of Acupuncture and Meridian, Anhui College of Traditional Chinese Medicine, Hefei 230038, R R. China

出　　处：《Journal of Acupuncture and Tuina Science》2010年第3期149-153,共5页针灸推拿医学（英文版）

摘　　要：Objective： To observe the influence on IL-1β and IL-2 in rat models with rheumatoid arthritis after moxibustion on Shenshu （BL 23） and Zusanli （ST 36） points, and to discuss the mechanism of moxibustion. Methods： Fifty male Wistar rats were divided randomly into 5 groups, control group, model group, drug group, moxibustion group, and laser group, 10 for each. Four groups except the normal group were built on the model of rheumatoid arthritis. The changes of body weight and plantar circumference were measured and the level of IL-1β, IL-2 in sera were examined by ELISA. Results： Compared with the model group, the weight and plantar circumference of rats in the moxibustion group were improved significantly after treatment （P〈0.01）, and the improvement of plantar circumference also had significant differences compared with the drug group and the laser group （P〈0.05）. The level of IL-1β, IL-2 in sera were down regulated in the moxibustion group and the laser group, which had statistical differences compared with the model group （P〈0.05）, but no statistical differences were found when comparing with the drug group. Conclusion： Moxibustion obviously improves the toe tumefaction of the rats with rheumatoid arthritis, which is better than CO2 laser of 10.6μm. On the aspect of decreasing the amount of IL-1β, IL-2, CO2 laser of 10.6μm is similar with moxibustion.目的：观察艾灸“肾俞”、“足三里”穴对类风湿关节炎大鼠细胞因子IL-1D、IL-2的影响，探讨艾灸效应的作用机制。方法：将50Wistar大鼠随机分为正常组、模型组、药物组、艾灸组及激光组，每组10只。除正常组大鼠外，其他4组大鼠复制类风湿关节炎大鼠模型，观察各组大鼠治疗前后体重、趾围的变化，ELISA法检测大鼠血液中IL-1β、IL-2的含量。结果：治疗后，艾灸组大鼠体重、跖围有显著改善，与模型组相比有非常显著性差异（P〈0．01），其中跖围改善与药物组及激光组比较有显著性差异（P〈0．05）；艾灸组及激光组均能下调类风湿关节炎大鼠血清中IL-1β、IL-2含量，与模型组比较，差异有统计学意义（P〈0．05），与药物纽比较，无显著性差异。结论：艾灸能显著改善类风湿关节炎大鼠的足跖肿胀，效果优于10．6μmCO2激光照射。在降低促炎症细胞因子IL—1β、IL-2含量方面，10．6μmCO2激光照射具有与艾灸相似的效应。

关 键 词：Moxibustion Therapy Arthritis  Rheumatoid Interleukin-1 beta INTERLEUKIN-2 Rats [CLC Number] R2-03 

分 类 号：R2-03[医药卫生—中医学]