本草基因组计划研究策略  

Strategies of the study on Herb Genome Program

作　　者：陈士林[1] 孙永珍[1] 徐江[1] 罗红梅[1] 孙超[1] 何柳[1] 程翔林 张伯礼[3] 肖培根[1] 

机构地区：[1]中国医学科学院、北京协和医学院药用植物研究所,北京100193 [2]中国生物技术发展中心,北京100036 [3]天津中医药大学,天津300193

出　　处：《药学学报》2010年第7期807-812,共6页Acta Pharmaceutica Sinica

摘　　要：本草基因组计划(HerbGP)是针对具有重大经济价值和典型次生代谢途径的药用植物进行的全基因组测序和后基因组学研究的系列计划。本文从物种选择,全基因组测序、组装和生物信息学分析,后基因组研究等方面系统阐述了本草基因组计划的研究策略。该计划将推动一批具有典型次生代谢途径的模式植物研究平台的建立,促进各种"组学"研究方法在药用植物研究领域中的应用,推动中国传统药学进入生命科学研究前沿领域。本草基因组计划为占领中药基础研究领域的科技制高点提供了难得的机遇,还将通过对药用植物有效成分生物合成路径的解析和药用植物优良品种的选育对我国天然药物的研发和中药农业的发展产生巨大而深远的影响。Herb Genome Program（HerbGP） includes a series of projects on whole genome sequencing（WGS） and post-genomics research of medicinal plants with unique secondary metabolism pathways or/and those of great medical and pharmaceutical importance.In this paper,we systematically discussed the strategy of HerbGP,from species selection,whole-genome sequencing,assembly and bioinformatics analysis,to postgenomics research.HerbGP will push study on Chinese traditional medicines into the front field of life science,by selecting a series of plants with unique secondary metabolism pathways as models and introducing ＂omics＂ methods into the research of these medicinal plants.HerbGP will provide great opportunities for China to be the leader in the basic research field of traditional Chinese medicine.HerbGP shall also have significant impacts on the RD of natural medicines and the development of medicinal farming by analysis of secondary metabolic pathways and selection of cultivars with good agricultural traits.

关 键 词：本草基因组计划 药用植物 全基因组测序 后基因组学 次生代谢 

分 类 号：R931.5[医药卫生—生药学]