视黄醛联合透明质酸抗皮肤老化功效及安全性评价  

Anti-aging efficacy and safety of topical preparations containing retinaldehyde and hyaluronate fragments

作　　者：周成霞[1] 李咏[1] 何黎[2] 杨蓉娅[3] 许爱娥[4] 项蕾红[5] 吴艳[6] 沈新 朱晓丹 Mery Sophie 李利[1] 

机构地区：[1]四川大学华西医院皮肤科,四川成都610041 [2]昆明医学院第一附属医院皮肤科,云南昆明650032 [3]北京军区总医院皮肤科,北京100700 [4]杭州市第三人民医院皮肤科,浙江杭州310009 [5]复旦大学附属华山医院皮肤科,上海200040 [6]北京大学第一医院皮肤科,北京100034 [7]雅漾医学护肤研究室-中国,上海200001 [8]雅漾医学护肤研究室-法国,法国81506

出　　处：《临床皮肤科杂志》2010年第7期420-422,共3页Journal of Clinical Dermatology

摘　　要：目的:观察外用0.05%视黄醛联合0.5%及1%透明质酸片段对中国人面部皮肤抗老化的功效性和安全性。方法:采用多中心研究,将受试者分为3组,分别于整个面部使用含0.05%视黄醛+0.5%透明质酸片段制剂;于深皱纹区域使用含0.05%视黄醛+1%透明质酸片段制剂及两种制剂联合应用。经90 d观察期,评估包括照片分级评分、面部肤色均匀度、皮肤干燥度、色素沉着、皮肤弹性及局部皱纹程度等多项老化指标,对2种外用制剂进行耐受性评估。结果:3组老化指标均有改善。照片分级评分降低,面部肤色均匀度改善,皮肤干燥度、色素沉着、皮肤弹性等皮肤老化体征均有改善。除1组受试者眉间纹外局部深皱纹程度均有改善。不良反应轻微。结论:视黄醛联合透明质酸片段外用可改善多种皮肤老化征象,安全有效。Objective：To investigate the anti-aging efficacy and safety of topical preparations containing 0.05% retinaldehyde and 0.5% or 1% hyaluronate fragments. Methods：Subjects were divided into 3 groups in this open design multicentre study, group 1 was applied with 0.05% retinaldehyde and 0.5% hyaluronate fragments on the whole face, group 2 with 0.05% retinaldehyde and 1% hyaluronate fragments on the areas presenting deep wrinkles, group 3 with the both. The photographic scale of facial photo-aging, skin color homogeneity, dryness, hyperpigmentation, skin elasticity were evaluated after 90 days and the toleration of the preparations assessed. Results：All the groups had improvements. The photographic scale of facial photo-aging decreased, and skin color homogeneity, dryness, hyperpigmentation, skin elasticity were improved. For each treatment group, the wrinkles except the glabella of group 1 released with mild adverse effect. Conclusion：Topical preparations containing retinaldehyde and hyaluronate fragments can improve skin aging with efficacy and safety.

关 键 词：视黄醛 透明质酸片段 抗老化 功效 安全性 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]