福建省人群胃食管反流病流行病学调查  

Epidemiologic survey on gastroesophageal reflux disease in the population of Fujian province

作　　者：沈许德[1] 王雯[2] 庄惠军[2] 

机构地区：[1]福建医科大学福总临床医学院消化内科,福州350025 [2]南京军区福州总医院消化科

出　　处：《中华消化杂志》2010年第6期386-390,共5页Chinese Journal of Digestion

基　　金：基金项目：南京军区医药卫生科研重点项目（07Z035）

摘　　要：目的 探讨福建省人群胃食管反流病（GERD）发病情况,分析与之相关的危险因素.方法 采用整群分层随机抽样的方法,对福建省福州市人群进行GERD症状及危险因素问卷调查.按反流病诊断问卷（RDQ）评分定义,总积分≥12分为GERD组,＜12分为非GERD组,对两组行相关因素分析.结果 共调查1347例对象,GERD患病率为8.76%（118/1347）.男女比例为1∶1.09,差异无统计学意义（x2=0.243,P＞0.05）.40岁以上人群GERD患病率较40岁以下人群明显增高（P＜0.05）.不同职业GERD患病率统计显示,商人患病率最高[17.91%（12/67）]、离退休者次之[13.48%（12/89）]、军人最低[2.94%（2/68）].GERD组中腹胀、嗳气、恶心、呕吐、纳差等症状的发生率及喉炎、咽炎、口腔溃疡等疾病的发生率均高于非GERD组（P＜0.01）.年龄、肥胖、吸烟、常食油腻、进食过饱、常食辛辣食物、常进甜食、常饮咖啡、常饮浓茶和便秘等可能是GERD的危险因素.结论 福建省人群GERD患病率较高,且多种因素与反流密切相关.Objective To assess the prevalence of gastroesophageal reflux disease（GERD） in the population of Fujian province, and to analyze the risk factors in relation to the disease. Methods A survey on GERD symptoms and its related factors was carried out in the population of Fuzhou city in Fujian province using a stratified random sampling method. According to reflux disease questionnaire （RDQ） score, the subjects were divided to GERD group with Sc≥ 12 and control group with Sc〈 12.The risk factors related to GERD were compared between two groups. Results A total of 1347residents were investigated. The prevalence of GERD was 8.76 %, and male to female ratio wasincreased in population above 40 years of age （P〈0.05）. The incidence of GERD in subjects with different occupations was as follows： the businessmen [17.91%（12/67）], retirees [13.48%（12/89）]and soldiers [2.94%（2/68）]. Symptoms including abdominal distension, belching, nausea, vomiting,dyspepsia were common in GERD group compared to control group （P 〈 0.01）. Besides, the laryngitis, pharyngitis and mouth ulcer were common in GERD group compared to control group （ P〈0.05）. The risk factors of GERD were eating greasy （OR= 1.589） and sweetmeat （OR= 2.413）,overeating （OR = 2.053）, constipation （OR = 1.650）, acridity food （OR = 1.366 ）, coffee （OR =1.295）, strong tea （OR= 1.362）. Conclusions The prevalence of GERD is high in the population of Fujian province, and many factors are closely related to reflux.

关 键 词：胃食管反流 流行病学研究 福建 

分 类 号：R571[医药卫生—消化系统]