共抑制分子PD-1的研究进展  

Research progress of co-inhibitory molecule PD-1

作　　者：郭国宁[1] 谢谆怡[2] 陈永文[2] 

机构地区：[1]第三军医大学附属西南医院急诊科,重庆400038 [2]第三军医大学附属西南医院全军免疫学研究所,重庆400038

出　　处：《免疫学杂志》2010年第7期639-642,共4页Immunological Journal

基　　金：国家自然科学基金(30700855及30971099)

摘　　要：免疫共抑制分子PD-1为CD28超家族成员,其最初是从凋亡的小鼠T细胞杂交瘤2B4.11克隆出来。PD-1基因敲除小鼠可诱导多种自身免疫性疾病,表明PD-1是一种重要的免疫抑制分子并在外周耐受中发挥着重要的作用。因此,以PD-1为靶点的免疫调节对抗肿瘤、抗感染、抗自身免疫性疾病及器官移植存活等均有重要的意义。PD-1,firstly cloned from mouse T cell hybridoma 2B4.11,belongs to members of CD28 superfamily.Some autoimmune diseases would be developed from PD-1 gene knocked out mice,which indicating that PD-1 is a co-inhibitory molecule which actively participates in maintaining peripheral tolerance.So,PD-1 would be a useful target for the immunologic therapy of carcinoma,infection,autoimmune diseases as well as organ transplantation in the near future.

关 键 词：PD-1 PD-L1 外周耐受 免疫调节 

分 类 号：R392.11[医药卫生—免疫学]