P^(16)蛋白在喉鳞癌中的表达与临床病理和吸烟的关系  

The Relationship between Expression of p^（16） Protein in Laryngeal Squamous Carcinoma and Clinical Pathology and Smoking

作　　者：沈帆[1] 施作霖[2] 张锟生[1] 江淑萍[2] 

机构地区：[1]福建省立医院耳鼻喉科,350001 [2]福建省立医院病理科,350001

出　　处：《齐齐哈尔医学院学报》1999年第1期6-8,共3页Journal of Qiqihar Medical University

基　　金：福建省卫生厅青年基金

摘　　要：目的：应用免疫组化技术SP法结合高压锅抗原修复对36例喉鳞癌P16蛋白的表达进行比较，观察P16蛋白的表述情况。探讨肿瘤抑制基因P16蛋白的表达与临床喉癌病理和吸烟的关系。应用X2检验及精确概率法分析P16蛋白表达与鳞癌分级、浸润深度及转移的相关性。结果：P16蛋白在喉鳞癌中的表达率为63．89％（23／36）；其中，高分化鳞癌P16蛋白的表达率为100％（6／6）；中分化鳞癌P16蛋白的表达率为66．67％（12／18）；低分化鳞癌P16蛋白的表达率为41．67％（5／12），显著低于高中分化组，差异有显著性意义（P＜0．05），结论：P16蛋白的表达与喉鳞癌的分期、浸润深度及转移密切相关。与病人的吸烟程度密切相关。Obiective: To study the expression of P16 protein and to probe the relatioaship between expression of tumor suppressor gene P16 and clinical pathology and smoking. Method: The immunofustochemical technique was used to detect the expression of P16 protein in 36 cases of laryngeal Squamous carcinoma. Results: The positive expressing rate of P16 protein in laryngeal squamous carcinoma was about 63. 89% (23/36), the expressing rate of P16 protein in high differentiating squamous carcinoma was about 66. 67 % (12/18). But the expressing rate of P16 protein in low differentiating squamous carcinoma was oniy 41. 67 % (5/12), and was greatly lower than of P16 protein in high and middle differentiating groups, there was a significant difference in P16 expressing rate between the low differentiating group and the high/middle group (P < 0. 05). Conclusion: The expression of P16 protein was closely related to clinical stagel invading extent, migration and smoking.

关 键 词：P^16蛋白 吸烟 临床病理学 喉肿瘤 

分 类 号：R739.650.2[医药卫生—肿瘤]