胆囊炎患者胆汁中内皮素浓度的意义  

Significance of the concentration of endothelins in bile in patients with cholecystitis

作　　者：肖永成[1] 杨辉[1] 夏先明[1] 雷正明[1] 刘宁[1] 

机构地区：[1]泸州医学院附属医院外科肝胆胰疾病研究室

出　　处：《中国普通外科杂志》1999年第2期141-142,共2页China Journal of General Surgery

摘　　要：目的探讨胆囊炎患者胆汁中内皮素浓度及其意义。方法采用放射免疫分析法测定了４０４例单纯型、４８例化脓型和２７例坏疽型结石性胆囊炎患者胆汁中内皮素浓度。结果三型胆囊炎患者胆汁内皮素浓度分别为２７４±８３ｐｇ／ｍｌ，４２３±１１１ｐｇ／ｍｌ和６７５±１３８ｐｇ／ｍｌ，与对照组测值１９４±４７ｐｇ／ｍｌ比较，具有显著性差异（Ｐ＜０．０５～０．０１）。结论胆汁中内皮素参与了胆囊炎的病理过程，其作用机制尚需深入研究。Objective To study the concentration and significance of endothelins in bile in the patients with cholecystitis. Methods The concentrations of endothelins were detected by radioimmunoassay in 404 cases of simple cholecystitis (SC), 48 cases of acute suppurative cholecystitis (ASC) and 27 cases of gagrenous cholecystitis (GC). Results The concentration of endothelins in bile in patients with SC, ASC and GC were 27.4±8.3pg/ml. 42.3±11.1pg/ml and 67.5±13.8pg/ml respectively. Compared with the control group (19.4±4.7pg/ml), the difference was significant ( P <0.05～0.01). Conclusions The endothelins in bile has some effect on the cholecystitis formation, but the pathogenesis should be further studied.

关 键 词：胆囊炎 胆汁代谢 内皮素 

分 类 号：R575.610.2[医药卫生—消化系统]