柯萨奇B组病毒所致面神经麻痹及神经系统病变  

AN INQUIRY INTO FACIAL NERVE PARALYSIS AND PATHOLOGIC CHANGES OF THE NERVOUS SYSTEM BY COXSACKIE B VIRUS(CBV)

作　　者：李英欣[1] 蒋惠荷[1] 陈艺琳[1] 吴国林[2] 宋文英[2] 邓爱琼[3] 

机构地区：[1]安徽省蚌埠医学院临床微生物教研室 [2]安徽省蚌埠医学院附属医院 [3]安徽省蚌埠市第一人民医院

出　　处：《河北医学》1999年第2期5-5,共1页Hebei Medicine

摘　　要：目的：报道５１例由柯萨奇Ｂ组病毒（ＣＯＸＳＡＣＫＩＲＥＢＶＩＲＵＳＣＢＶ）所致面神经麻痹及神经系统病变；方法：采用酶联免疫吸附试验（ＥＬＩＳＡ）技术。静脉取血１ｍｌ分离血清，检查血清中的ＣＢＶ抗体Ⅰ～Ⅵ型；结果：病毒性脑膜炎２９例，面神经麻痹８例，双肢或四肢肌无力８例，癫痫４例，带状疱疹２例。最小年龄３岁，最大年龄７２岁。临床均给予抗病毒治疗，效果显著；结论：人是柯萨奇病毒唯一的天然宿主，接触是其重要的感染方式，柯萨奇Ｂ组病毒不但能致其它脏器病变，也能致神经系统病变。临床对可疑患者选择ＣＢＶ特异性抗体检查。Objective:This article reports 51 cases in which facial nerve paralysis and pathologic changes of the nervous system were caused by Coxsackie B virus(CBV).Methods:ELISA was employed.Serum was separated from a vein and CBV antibody Ⅰ～Ⅵ in the serum was detected. Results:Viral meningitis 29 cases;facial nerve paralysis muscle weakness in two limbs or four 8 cases;epilepsy 4 cases;zoster 2 cases;the youngest patient,3 years of age;the oldest patient,72 years of age; All patients were clinically given antiviral treatment,which resulted in remarkable effcets.Conclusion:Men are the sole natural hosts of Coxsackie B virus and contct is the major infecting way.Coxsackie B virus is able to make both visera and nervous system develop pathologic changes.Clinically the suspected patients may be given CBV special viral antibody detection,which is a simpler,faster and more reliable diagnostic method.

关 键 词：柯萨奇B组病毒 神经系统病变 面神经麻痹 

分 类 号：R745.120.4[医药卫生—神经病学与精神病学] R741.04[医药卫生—临床医学]