喷雾干燥法制备丹参酮ⅡA自乳化微丸  

Preparation of TanshinoneⅡA Self-emulsifying Micro-pill by Spray Drying Method

作　　者：杨静[1] 韩静[1] 孙铭[1] 张玥[1] 张多婷[1] 项文娟[1] 

机构地区：[1]沈阳药科大学制药工程学院,110016

出　　处：《医药导报》2010年第7期920-922,共3页Herald of Medicine

摘　　要：目的采用喷雾干燥法制备以聚乙烯吡咯烷酮(PVP)为增溶剂的丹参酮ⅡA自乳化微丸。方法以包封产率为指标,考察不同处方和工艺因素的影响,采用L9(34)正交设计对处方和工艺进行优化。提高丹参酮ⅡA的稳定性和生物利用度。结果喷雾干燥最佳工艺条件为:进风温度为115℃,空气流速为500 L.h-1,PVP水溶液的质量浓度为0.01 g.mL-1,丹参酮ⅡA与PVP的比例为1:6。结论丹参酮ⅡA自微乳制备简单,性质稳定,丹参酮ⅡA在介质中的溶出度较好。采用喷雾干燥法制备丹参酮ⅡA自微乳微丸可行。Objective To prepare self-emulsifying micro-pills by using the spray drying method. Methods The encapsulation efficiency was considered to evaluate the influence of different formulation and preparation factors.The formulation was optimized by L9（34） orthogonal design to improve stability and oral bioavailability of tanshinoneⅡA. Results The optimum processing conditions were as follows： inlet-air temperature at 115 ℃,air flow rate at 500 L·h-1,PVP（aq） concentration as 0.01 g·mL-1,ratio of PVP to tanshinoneⅡA as 1：6. Conclusion The preparation of the self-micro emulsified tanshinoneⅡA is easy,stable and with remarkable solubility.The method of spray drying is feasible for the preparation of tanshinoneⅡA self-emulsifying micro-pill.

关 键 词：丹参酮ⅡA 喷雾干燥 自乳化微丸 

分 类 号：R944.2[医药卫生—药剂学] TQ460.6[医药卫生—药学]