恶性肿瘤特异性生长因子的检测及其临床意义  

Assay of serum tumor specific growth factor and its clinial significance in malignancies

作　　者：刘昌俊[1] 陈珠峰[1] 王民玉[1] 毕峰[1] 

机构地区：[1]山东省千佛山医院

出　　处：《齐鲁肿瘤杂志》1999年第1期19-20,共2页

摘　　要：目的评价肿瘤特异性生长因子（ＴＳＧＦ）诊断肿瘤的价值及其临床意义。方法血清中ＴＳＧＦ与显色剂呈显色反应，测其吸光度，查标准曲线，求出ＴＳＧＦ含量，并设健康组、肺感染组和慢性肝炎组作为对照组。结果８３例肿瘤病人血清ＴＳＧＦ含量（７１．１２±１１．０３ｕ／ｍｌ）显著高于３０例健康对照组（Ｐ＜０．００１）、３０例肺感染组（Ｐ＜０．００１）和３０例慢性肝炎组（Ｐ＜０．００１）。ＴＳＧＦ在肺癌、消化系统和泌尿生殖系肿瘤中的阳性率显著高于ＣＥＡ阳性率（Ｐｔ＞２）。２２例化疗有效者血清ＴＳＧＦ含量较化疗前显著降低（Ｐ＜０．００１），８例恶化者则显著升高（Ｐ＜０．００１）。检测肿瘤血清ＴＳＧＦ的敏感性、特异性和准确性分别为９１．５７％、９６．６０％和９２．０４％。结论ＴＳＧＦ是一种新的敏感性和特异性较高的广谱肿瘤标志物，对肿瘤的辅助诊断、疗效评价和预示肿瘤复发具有重要临床意义。Objective To evaluate the value of TSGF in diagnosis of tumor and its clinical significance Methods TSGF in serum and chromoparic material cause a chromoparic reaction in a certain condition,then the absorbance can be measured by chromatoptometer.The concentration of TSGF was got from the standard curve.The normal persons,the patients of lung infection and the chronic hepatitis were control groups.Results The serum TSGF Level of patients with tumor (71.12±11.03u/ml)was significantly higher than that of 30 cases of normal persons(51.23±8.92u/ml,P< 0.001 ),30 cases with lung infection (57.12±9.86u/ml,P<0.001) and 30 cases with chronic hepatitis (51.43± 12.38 u/ml,P<0.001).The sensitivity, specificity and accuracy of TSGF in diagnosis of tumor were 91.57%,96.60% and 92.04%, respctively.There was no significant difference in TSGF positive rate among these patients with lung cancer (95.45%),digestive systematic tumor (92.11%)and urinary and reproductive tumor(87.5%),but obvious higher than that of CEA(Pt>2).Out of 30 patients received chemotherapy,TSGF level of 22 responsed patients was significantly lower than that of prechemotherapy (P<0.001),whereas 8 cases with tumor deterioration was obvious higher(P<0.001).Conclusion Serum TSGF is a sensitivity,specificity,accuracy and broad spectrum new tumor marker.

关 键 词：肿瘤标志物 特异性生长因子 肿瘤 诊断 

分 类 号：R730.43[医药卫生—肿瘤]