生存素和磷酸化信号传导与转录激活因子3在脑胶质瘤组织中表达与相互关系的研究  

Expressions of survivin and p-STAT3 in tumor tissue of brain glioma and their corrlations

作　　者：王新华[1] 杨炼球[1] 邱令云[2] 周勇军[1] 李龙平[1] 张华[1] 

机构地区：[1]中南大学湘雅医学院益阳临床学院临检中心,湖南省益阳市413000 [2]中南大学湘雅医学院益阳临床学院神经外科,湖南省益阳市413000

出　　处：《中国医药》2010年第8期687-688,共2页China Medicine

摘　　要：目的探讨脑胶质瘤组织中生存素和磷酸化信号传导与转录激活因子3（p-STAT3）表达与相互关系及其在脑胶质瘤发生发展过程中的作用。方法应用免疫组织化学即用型二步法检测62例脑胶质瘤和10例正常脑组织中生存素和p-STAT3的表达情况。结果生存素和p-STAT3在正常脑组织中不表达；在脑胶质瘤中，生存素和p-STAT3高表达，阳性率分别为56．45％、61．29％，Kemohan分级Ⅲ＋Ⅳ级与Ⅰ＋Ⅱ级生存素和p-STAT3阳性表达差异有统计学意义（P〈0．05）；在35例生存素阳性表达病例中，p-STAT3表达阳性25例（71．43％），生存素蛋白与p-STAT3蛋白的表达呈正相关（r00．38，P=0．003）。结论生存素基因可能是通过p-STAT3蛋白的激活在脑胶质瘤组织中发挥抗凋亡作用，促进脑胶质瘤发生及发展。Objective To investigate the expressions of survivin and p-STAT3 in the tumor tissue of brain glioma, their eorriations and the role in the development and progression of brain glioma. Methods Simple twostep immunohistoebemieal staining was used for the measurement of the expressions of the survivin and p-STAT3 between 62 cases of brain glioma and 10 normals. Results No expressions of the survivin and p-STAT3 were noted in the normal brain tissue, while high expressions of them were done in brain glioma, with the positive rate of 56.45 and 61.29% respectively. There was a markedly significant difference in the expressions of the survivin and p- STAT3 between Kernohan＇s Grade 3-4 and 1-2, P 〈0.05. Of 35 survivin-positive cases, 25（71.43% ） were p- STAT3-positive, and the expression of the survivin protein was directly related to that of p-STAT3 （r =0. 38, P = 0.003 ）. Coudusion Survivin gene may play the anti-apoptotie function in the turmor tissue of brain glioma through activating the p-STAT3 protein, faeiliating the development and progression of the glioma.

关 键 词：脑胶质瘤 生存素 磷酸化信号传导与转录激活因子3 

分 类 号：R739.4[医药卫生—肿瘤]