金刚烷胺对帕金森病患者角膜内皮细胞损害作用的研究  

Adverse reaction of amantadine on corneal endothelial cells in patients with Parkinson's disease

作　　者：陆学胜[1] 朱天夫[1] 许敏[1] 张燕[1] 姚胜旗[1] 张允[1] 朱筱琦[1] 

机构地区：[1]上海市长宁区中心医院神经内科,上海200336

出　　处：《世界临床药物》2010年第7期417-421,共5页World Clinical Drug

摘　　要：目的评估金刚烷胺对帕金森病(PD)患者角膜内皮细胞的损害作用。方法对120例口服金刚烷胺的PD患者(金刚烷胺治疗组)、30例未服用金刚烷胺的PD患者及50例非PD对照者进行横断面调查。通过裂隙灯显微镜检,比较各组内皮细胞密度、六角形细胞出现率和细胞变异系数的差异。本研究同时就累积剂量和治疗持续时间对金刚烷胺治疗组6个亚组的上述指标,与对照组进行比较。结果非PD对照组、未服用金刚烷胺的PD组及金刚烷胺治疗组患者角膜内皮细胞的平均密度分别为(2825.3±52.4)/mm2、(2820.8±46.9)/mm2和(2659.5±32.1)/mm2;六角形细胞出现率分别为(59.2±1.2)%、(61.9±0.9)%和(57.1±1.2)%;变异系数分别为(34.0±1.3)、(33.1±1.0)和(37.5±0.7),金刚烷胺治疗组各指标与未服用金刚烷胺的PD组和非PD对照组患者相比,差异均有统计学意义的显著性(P<0.05)。金刚烷胺治疗组各亚组比较结果提示,角膜内皮细胞平均密度和六角形细胞出现率随金刚烷胺服用剂量的增加和服用时间的延长呈下降趋势。结论口服金刚烷胺可造成患者角膜内皮细胞损伤,其作用可能有时间和剂量依赖性。Objective To assess the adverse reaction of amantadine on corneal endothelial cells in patients with Parkinson＇s disease （PD）. Methods A cross-sectional study was performed among 120 PD patients who were administered with amantadine （amantadine-treated group）, 30 PD patients who were not administered with amantadine （non- amantadine-treated group）, and 50 non-PD patients （non-PD control group）. Endothelial cell density, occurrence rate of hexagonal cells, and coefficient of variation were measured by slit-lamp biomicroscopy and were compared among 3 groups. The amantadine-treated group was further divided into six sub-groups according to the cumulative dose and duration of treatment. Results Mean endothelial cell density of non-PD control group, non-amantadine-treated group and amantadine-treated group were （2825.3 ＋ 52.4）/mm2, （2820.8 ＋ 46.9）/mm2 and （2659.5 ＋ 32.1）/mm2 respectively. Occurrence rate of hexagonal cells in non-PD control group, non-amantadine-treated group and amantadine-treated group were （59.2±1.2） %, （61.9±0.9） % and （57.1 ± 1.2） % respectively. Coefficient of variation in non-PD control group, non- amantadine-treated group and amantadine-treated group were （34.0± 1.3）, （33.1± 1.0） and （37.5 ±0.7） respectively. There were significant differences between amantadine-treated group and non-PD control group or amantadine-treated group and non-amantadine-treated group （P〈0.05）. Longer duration and higher cumulative dose of amantadine therapy led to a greater reduction in endothelial cell density and occurrence rate of hexagonal cells. Conclusions Amantadine may induce adverse reaction on comeal endothelial cells, in a dose- and duration-dependent manner.

关 键 词：金刚烷胺 角膜内皮细胞 不良反应 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R971.5[医药卫生—临床医学]