乏氧诱导因子-1α和血管内皮生长因子C及CD44v6在食管鳞癌中的表达及其临床意义  

Expression of Hypoxia-inducible Factor-1α and Vascular Endothelial Growth Factor-C and CD44v6 in Esophageal Squamous Cell Carcinoma Tissues

作　　者：朱辉[1] 贺春语[1] 王慧娟[1] 王启鸣[1] 李鹏[1] 闫相涛[1] 王生[2] 马智勇[1] 

机构地区：[1]河南省肿瘤医院内科,河南省郑州市450008 [2]郑州大学第一附属医院肿瘤科

出　　处：《中国全科医学》2010年第20期2203-2205,共3页Chinese General Practice

基　　金：2005年河南省医学科技攻关计划(92)

摘　　要：目的探讨食管鳞状细胞癌(ESCC)中乏氧诱导因子-1α(HIF-1α)、血管内皮生长因子C(VEGF-C)和CD44v6蛋白的表达情况及其与食管癌临床病理特征的关系。方法选择58例ESCC患者,取其手术标本或胃镜活检病理组织,采用免疫组织化学SP法检测ESCC组织中HIF-1α、VEGF-C和CD44v6蛋白的表达。结果 58例患者的ESCC组织中,HIF-1α、VEGF-C和CD44v6均呈高表达,阳性表达率分别为51.7%、53.4%和60.3%。不同性别、临床分期、分化程度的患者,其ESCC组织中HIF-1α、VEGF-C和CD44v6的阳性表达率间差异无统计学意义(P>0.05),而淋巴结转移者ESCC组织中VEGF-C和CD44v6的阳性表达率显著高于无淋巴结转移者,差异有统计学意义(P<0.05)。HIF-1α表达与VEGF-C表达呈相关(P<0.05)。结论 VEGF-C、CD44v6表达与淋巴结转移有关,检测二者可作为判定ESCC侵袭转移能力的客观指标,而HIF-1α表达在食管癌淋巴结转移中的作用尚待进一步扩大样本验证。Objective To investigate the expressions of hypoxia - inducible factor - 1α （ HIF - 1 α ） , vascular endothelial growth factor - c （ VEGF - C） , CD44v6 in esophageal squamous cell carcinoma （ESCC） tissues and its relationship to the clinicopathalogy features of ESCC. Methods The expression of HIF - 1α, VEGF - C and CD44v6 were detected by immnohistochemical staining in 58 ESCC patients. Results In the ESCC tissues of 58 ptaients, HIF - 1 α, VEGF - C and C and CD44v6 were highly expressed, with positive rates of 51.7%, 53.4%, 60. 3%, respectively, which were not correlated with sex, clinical stage and degree of differentiation （ P 〉 0. 05 ）, but VEGF - C and CD44V6 correlated with lymph metastasis （ P 〈 0.05 ）. The positive expression of HIF - 1a was related to VEGF - C （ P 〈 0.05 ）. Conclusion The expressions of VEGF - C and CD44v6, correlated with lymph node metastasis, can be used as an objective indicator for ESCC invasion and metastasis ability. But the role of HIF - 1 αexpression in esophageal cancer lymph node metatasis is to be further verified with more samples.

关 键 词：食管肿瘤 肿瘤 鳞状细胞 缺氧诱导因子1 Α亚基 血管内皮生长因子C CD44V6 

分 类 号：R735.1[医药卫生—肿瘤]