胸腔镜下热灌注化疗治疗恶性胸腔积液的疗效观察  

Pleural perfusion thermo-chemotherapy for malignant pleural effusion(MPE) under VATS

作　　者：张竞雄[1] 

机构地区：[1]杭州市第一人民医院胸外科,浙江杭州310006

出　　处：《临床肺科杂志》2010年第8期1083-1084,共2页Journal of Clinical Pulmonary Medicine

摘　　要：目的探讨胸腔镜下热灌注化疗对恶性胸腔积液患者的治疗效果。方法 44例恶性胸腔积液患者于全麻下用胸腔镜探察胸腔,并行胸膜活检,用人工心肺机将预充液(NS3000ml+顺铂300mg)加热至42.0～44.0℃后,通过两根导管连接至胸腔内,循环灌注胸腔约60min。结果胸水控制有效率为97.7%,KPS评分升高率为70.4%,未见明显的毒副作用。结论胸腔镜下胸腔内热灌注化疗具有快速诊断、创伤小、控制胸水效果好、副作用小的优点。Objective To assess the comprehensive effective of pleural perfusion thermo-chemotherapy（PPTC） for malignant pleural effusion（MPE） under VATS.Methods 44 patients with MPE underwent pleural biopsy of the primary lesions and PPTC under VATS without thoracotomy.PPTC consists of irrigating the pleural space with 43.0 degrees C saline（3000 ml） solution containing cisplatin（300 mg） using a devised circuitcircular intrapleural hyperthermic perfusion with 42.0 ～ 44.0 degrees C warmed normal saline for 60 minutes.The control rate of pleural effusion,Karnofsky performance status（KPS） grade,side-effects of the patients was calculated.Results The Treatment group achieved control rate of 97.7%.Increasing of Karnofsky performance status（KPS） grade were 70.4%.There was no significant side effect.Conclusion Pleural perfusion thermo-chemotherapy under VATS is a new,safe,less invasive and more effective approach for for malignant pleural effusion（MPE）.

关 键 词：胸腔镜 恶性胸腔积液 热化疗 

分 类 号：R730.5[医药卫生—肿瘤]